Quantifying the passage of the large peptide protamine (Ptm) across CymA, a passive channel for cyclodextrin uptake, is in the focus of this study. Using a reporter-pair-based fluorescence membrane assay we detected the ...

Antibiotics enter into bacterial cells via protein channels that serve as low-energy pathways through the outer membrane, which is otherwise impenetrable. Insights into the molecular mechanisms underlying the transport ...

The voltage-dependent transport through biological and artificial nanopores is being used in many applications such as DNA or protein sequencing and sensing. The primary approach to determine the transport has been to ...

Chirality is essential in nearly all biological organizations and chemical reactions but is rarely considered due to technical limitations in identifying L/D isomerization. Using OmpF, a membrane channel from Escherichia ...

In the present work, we delineate the molecular mechanism of a bulky antibiotic permeating through a bacterial channel and uncover the role of conformational dynamics of the constriction loop in this process. Using the ...

Residing in the 5′ untranslated region of the mRNA, the 2′-deoxyguanosine (2′-dG) riboswitch mRNA element adopts an alternative structure upon binding of the 2′-dG molecule, which terminates transcription. RNA conformations ...

Riboswitches are non-coding RNA sequences that control cellular processes through ligand binding. Conformational heterogeneity is fundamental to riboswitch functionality, yet this same attribute makes structural characterization ...

During infection, plant-secreted hydrolases play a prominent role in defense and are often targeted by pathogens. We recently discovered that Pseudomonas syringae produces a small molecule inhibitor ‘galactosyrin’ to ...

A search is presented for an extended Higgs sector with two new particles, 𝑋 and 𝜙 , in the process 𝑋→𝜙⁢𝜙→(𝛾⁢𝛾)⁢(𝛾⁢𝛾) . Novel neural networks classify events with diphotons that are merged and determine the ...

A search is presented for fractionally charged particles with charges below 1⁢𝑒 , using their small energy loss in the tracking detector as a key variable to observe a signal. The analyzed dataset corresponds to an ...