| dc.contributor.author |
Kumar, Indresh |
|
| dc.date.accessioned |
2025-07-25T07:09:09Z |
|
| dc.date.available |
2025-07-25T07:09:09Z |
|
| dc.date.issued |
2023-10 |
|
| dc.identifier.uri |
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/ejoc.202300901 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/jspui/handle/123456789/19091 |
|
| dc.description.abstract |
A simple and straightforward method is developed for the enantioselective synthesis of indol-3-yl-piperidine. The reaction proceeds through a proline-catalyzed direct Mannich reaction between glutaraldehyde and C3-indolyl-imines, followed by intramolecular reductive cyclization as an overall [4+2] annulation in one-pot fashion. A series of indol-3-yl-piperidine have been accessed with good yields up to 71 % and high enantioselectivity up to >99 % ee. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Wiley |
en_US |
| dc.subject |
Chemistry |
en_US |
| dc.subject |
Indol-3-yl-piperidine |
en_US |
| dc.subject |
Enantioselective synthesis |
en_US |
| dc.subject |
Reductive cyclization |
en_US |
| dc.subject |
Glutaraldehyde |
en_US |
| dc.title |
Organo-catalyzed enantioselective [4+2] Annulation of glutaraldehyde and c3-indolyl-imines to access indol-3-yl-piperidines |
en_US |
| dc.type |
Article |
en_US |