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Browsing Department of Biological Sciences by Author "Dubey, Uma S."

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Calcium chloride linked camel milk deried casein nanoparticles for the delivery of sorafenib in hepatocarcinoma cells

Dubey, Uma S. (TSP, 2021)

Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma, is limited by its low oral bioavailability. To overcome this drawback, we have developed novel camel milk casein-derived nanoparticles ...
Counteracting Microbes

Dubey, Uma S. (‎ Nova Science Publishers, 2013)
Dynamics of an SIR Model with Nonlinear Incidence and Treatment Rate

Dubey, Uma S.; Dubey, Balram (AAM, 2015-12)

In this paper, global dynamics of an SIR model are investigated in which the incidence rate is being considered as Beddington-DeAngelis type and the treatment rate as Holling type II (saturated). Analytical study of the ...
Effect of elevated temperature on natural killer cell and antibody-dependent cellular eytoboxieity

Dubey, Uma S. (HALOCYNTHIA ASSOCIATION, 1998)

Several studies have shown a direct correlation between temperature and immune response. The effect of elevated temperature on cytotoxic effector functions is not well known. In the present study we have investigated the ...
Epidemiology of breast cancer in Indian women

Dubey, Uma S. (Wiley, 2017-02-09)

Breast cancer has ranked number one cancer among Indian females with age adjusted rate as high as 25.8 per 100,000 women and mortality 12.7 per 100,000 women. Data reports from various latest national cancer registries ...
Evolution Of Classification Of Bladder (Urothelial) Cancer Bladder Cancer Classification

Dubey, Uma S. (NICPD, 2015)

The classification of bladder tumors has undergone a change over the years but still has not achieved success in predicting the behavior. The correct cellular classification of a tumor helps initiate appropriate treatment. ...
Gene deleted live attenuated Leishmania vaccine candidates against visceral leishmaniasis elicit pro-inflammatory cytokines response in human PBMCs

Dubey, Uma S. (Nature, 2016)

Currently no effective vaccine is available for human visceral leishmaniasis(VL) caused by Leishmania donovani. Previously, we showed that centrin1 and p27gene deleted live attenuated Leishmania parasites (LdCen1−/− and ...
A MATHEMATICAL MODEL FOR THE EFFECT OF TOXICANT ON THE IMMUNE SYSTEM

Dubey, Uma S.; Dubey, Balram (World Scientific, 2007)

In this paper, a nonlinear mathematical model is proposed and analyzed to study the effect of environmental toxicant on the immune response of the body. Criteria for local stability, instability and global stability are ...
MODELING AND ANALYSIS OF AN SEIR MODEL WITH DIFFERENT TYPES OF NONLINEAR TREATMENT RATES

Dubey, Uma S.; Dubey, Balram (World Scientific, 2013)

In this study, an SEIR epidemic model is proposed for treatment of infectives considering the development of acquired immunity in recovered individuals. We employed two different types of treatment functions. Stability ...
MODELING EFFECTS OF TOXICANT ON UNINFECTED CELLS, INFECTED CELLS AND IMMUNE RESPONSE IN THE PRESENCE OF VIRUS

Dubey, Uma S.; Dubey, Balram (World Scientific, 2011)

In this paper, two mathematical models are proposed and analyzed. The first one deals with the interaction of uninfected cells, infected cells, viruses and immune response within humans. The second one deals with the effects ...
Modeling the dynamics of viral–host interaction during treatment of productively infected cells and free virus involving total immune response

Dubey, Uma S.; Dubey, Balram (VUP, 2021)

Virus dynamics models are useful in interpreting and predicting the change in viral load over the time and the effect of treatment in emerging viral infections like HIV/AIDS, hepatitis B virus (HBV). We propose a ...
MODELING THE INTERACTION BETWEEN AVASCULAR CANCEROUS CELLS AND ACQUIRED IMMUNE RESPONSE

Dubey, Uma S.; Dubey, Balram (World Scientific, 2008)

This paper deals with the interaction between dispersed cancer cells and the major populations of the immune system, namely, the T helper cells, T Cytotoxic cells, B cells, and antibodies produced. The system is described ...
Modeling the intracellular pathogen-immune interaction with cure rate

Dubey, Uma S.; Dubey, Balram (Elsiever, 2016-09)

Many common and emergent infectious diseases like Influenza, SARS, Hepatitis, Ebola etc. are caused by viral pathogens. These infections can be controlled or prevented by understanding the dynamics of pathogen-immune ...
Modeling the role of acquired immune response and antiretroviral therapy in the dynamics of HIV infection

Dubey, Uma S.; Dubey, Balram (Elsiever, 2018-02)

This paper deals with the study of a virus dynamics model in order to get better insights into HIV infection within the body. The model incorporates therapeutic modalities such as reverse transcriptase inhibitors (RTIs) ...
OPTIMAL CONTROL FOR THERAPEUTIC DRUG TREATMENT ON A DELAYED MODEL INCORPORATING IMMUNE RESPONSE

Dubey, Uma S.; Dubey, Balram (World Scientific, 2015)

Millions of people get infected every year by viral pathogens. Newly emergent diseases such as Ebola, Swine-flu, HIV/AIDS, etc. are spreading worldwide at an alarming rate. We introduced a delayed mathematical model with ...
Quinoline Glycoconjugates as Potentially Anticancer and Anti-Inflammatory Agents: An Investigation Involving Synthesis, Biological Screening, and Dockin

Dubey, Uma S.; Sah, Ajay Kumar; Shukla, Paritosh (ECSP, 2020-08-20)

The present work is a preliminary report of synthesis of a series of targeted 4,6-O-ethylidene-β-D-glucopyranosylamine glycoconjugate quinoline 4-carboxylic acid derivatives followed by a quick evaluation of their ...
Research Journal of Pharmaceutical, Biological and Chemical Sciences

Dubey, Uma S. (RJPBCS, 2020)

α-lactalbumin-Oleic acid complex derived from milk is well known to have anti-cancer properties in many diverse mammalian species including humans, goats and cows. The objective of the current study is to see if α-lactalbumin ...
An SIR Model with Nonlinear Incidence Rate and Holling Type III Treatment Rate

Dubey, Uma S.; Dubey, Balram (Digital Science, 2016-12)

We propose a mathematical model with nonlinear incidence rate and treatment rate to study the dynamics of susceptible-infected-recovered population. We consider nonlinear incidence rate as Crowley-Martin type and nonlinear ...
Study on the effects of Cl and F doping in TiO2 powder synthesized by a sol-gel route for biomedical applications

Dubey, Uma S. (Elsiever, 2019-11)

F- and Cl-doped (10 at%) TiO2 powders were prepared by a sol-gel route and calcined at different temperatures and for different times. X-ray diffraction, thermogravimetric- and differential-thermal analysis showed that ...
THERAPEUTIC POTENTIAL OF CAMEL MILK

Dubey, Uma S.; Kapur, Suman (EJFA, 2016)

Camel milkis recognized for its therapeutic potential against many diseases. It is reported to have microbicidal and immuno stimulatory properties as it contains immunoactive proteins like lysozyme, lactoperoxidase and ...

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