Department of Biological Sciences: Recent submissions

Now showing items 1-20 of 702

Repurposing of CNS accumulating drugs Gemfibrozil and Doxylamine for enhanced sensitization of glioblastoma cells through modulation of autophagy

Mukherjee, Sudeshna; Chowdhury, Rajdeep; Majumder, Syamantak; Chowdhury, Shibasish (Springer Nature, 2025-07)

GBM is one of the most aggressive malignancies, having the greatest fatality rate and average life years lost. The current standard medicine, temozolomide (TMZ), is ineffective, requiring the development of new treatments. ...
Metabolomic profiling of biphenyl-induced stress response of Brucella anthropi MAPB-9

Jha, Prabhat Nath; Paul, Atish Tulsiran (Springer Nature, 2025-04)

The exposure of bacteria to toxic compounds such as polychlorinated biphenyl (PCB) and biphenyl induces an adaptive response at different levels of cell morphology, biochemistry, and physiology. PCB and biphenyl are highly ...
Unraveling PPARβ/δ nuclear receptor agonists via a drug-repurposing approach: HTVS-based ligand identification, molecular dynamics, pharmacokinetics, and in vitro anti-steatotic validation

Sharma, Pankaj Kumar; Murugesan, Sankaranarayanan; Deepa, P.R. (RSC, 2025-04)

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated nuclear receptors with a crucial regulatory role in carbohydrate and lipid metabolism and are emerging druggable targets in “metabolic syndrome” ...
Impact of climate change on soil health and nutrient cycling

Joshi, Mukul (CABI, 2025-03)

The soil environment is influenced by different parameters and processes including topography, climate and parent material throughout the landscape. Major soil properties including, (i) soil moisture which plays a fundamental ...
Advances in using non-thermal plasmas for healthier crop production: toward pesticide and chemical fertilizer-free agriculture

Joshi, Mukul (Springer, 2025-04)

There is an urgent need to transform agricultural practices to meet the challenges of sustainable food production amidst global population growth and environmental degradation. Traditional crop production methods heavily ...
Transcriptomic profiling of desert tree Prosopis cineraria under heat stress reveals potential role of multiple gene families in its high thermotolerance

Joshi, Mukul (2025)

The static nature of plants restrains their potential to evade heat stress and requires them to withstand stress through inherent defence abilities. Prosopis cineraria is a leguminous phreatophyte distributed across arid ...
Bacterial pathogen deploys the iminosugar glycosyrin to manipulate plant glycobiology

Chandrasekar, Balakumaran (AAAS, 2025-04)

The extracellular space (apoplast) in plants is a key battleground during microbial infections. To avoid recognition, the bacterial model phytopathogen Pseudomonas syringae pv. tomato DC3000 produces glycosyrin. Glycosyrin ...
Natural fiber and nanoparticles reinforced natural fiber for structural composite applications

Roy, Banasri (Springer, 2023-02)

The plant based natural fibers (mostly made of cellulose, hemi cellulose, and lignin) provide several advantages over the traditional inorganic fibers including their low density, good thermal insulation and mechanical ...
Proteomics analysis in urinary bladder cancer patients identifies urinary SOD2 as a predictive marker of recurrence

Dubey, Uma S. (2021-12)

Early non-invasive detection of tumor is an urgent clinical need for managing urothelial bladder cancer. Cystoscopy and cytology are the current standards for diagnosis of recurrence, but are limited by low sensitivity. ...
Calcium chloride linked camel milk derived casein nanoparticles for the delivery of sorafenib in hepatocarcinoma cells

Dubey, Uma S. (Tech Science Press, 2021-09)

Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma, is limited by its low oral bioavailability. To overcome this drawback, we have developed novel camel milk casein-derived nanoparticles ...
Medicinal potential of Camel milk lactoferrin

Dubey, Uma S. (Intecopen, 2022)

Camel milk is a rich source of protein with well-recognized medicinal properties to treat various diseases. The objective of this work is to understand the role of camel milk lactoferrin in immunomodulation and in disease ...
Studies on cytotoxic activity of Camel milk whey protein as a nutraceutical against HeLa cells

Dubey, Uma S. (Camel Publishing House, 2023)

Camel milk is an adapted dietary supplement with multiple antimicrobial and immuno-stimulatory properties. Diabetes, infant diarrhoea, hepatitis, allergy, lactose intolerance, and alcohol- induced liver damage have ...
Aberrant expression of col14a1, celrs3, and cthrc1 in breast cancer сells

Dubey, Uma S. (Experimental oncology, 2023)

Collagens, which are the major components of the extracellular matrix involved in the regulation of tumor microenvironment, could be differentially expressed in breast cancer (BC) with different transcriptome profiling. ...
Evaluation of the cytotoxic activity of sorafenib-loaded camel milk casein nanoparticles against hepatocarcinoma cells

Dubey, Uma S. (Wiley, 2024-03)

Sorafenib, a multikinase inhibitor is used to treat hepatocellular and renal carcinoma. However, a low solubility impedes its bioavailability and thus, effectiveness. This study aims to enhance its effectiveness by using ...
Modeling the effect of vaccinations, hospital beds, and treatments on the dynamics of infectious disease with delayed optimal control and sensitivity analysis

Dubey, Uma S.; Dubey, Balram (Springer, 2024-08)

Immunization plays a vital role in eradicating infectious diseases, typically requiring multiple doses at specific time intervals. This study focuses on developing and analyzing an infectious disease model governed by a ...
Impact of chemo-immunotherapy on tumour-immune interactions: a non-autonomous model of tumor necrosis factor and T cell dynamics

Dubey, Uma S.; Dubey, Balram (2025)

This study explores the interaction between cancer cells, helper T cells, cytotoxic T cells, and tumour necrosis factors in chemotherapy and immunotherapy treatment in the microenvironment [1]. The goal is to analyze the ...
Bifurcation and chaotic dynamics in a spatiotemporal epidemic model with delayed optimal control, stochastic process, and sensitivity analysis

Dubey, Uma S.; Dubey, Balram (AIP, 2025-03)

This study introduces an epidemic model with a Beddington–DeAngelis-type incidence rate and Holling type II treatment rate. The Bedding- ton–DeAngelis incidence rate is used to evaluate the effectiveness of inhibitory ...
Evaluation of interleukin-33 & sST2 levels in type-2 diabetic mellitus patients with or without metabolic syndrome

Majumder, Syamantak (Indian Journal of Medical Research, 2023)

Diabetes mellitus (DM) is characterized by increase in blood glucose levels due to defective insulin secretion or insulin sensitivity. Interleukins (ILs) are known to play an important role in the pathogenesis of DM. The ...
Chloroquine attenuates hypoxia-mediated autophagy to curb thrombosis- an ex vivo and in vivo study

Mukherjee, Sudeshna; Majumder, Syamantak; Chowdhury, Shibasish; Chowdhury, Rajdeep (2024-04)

Hypoxia can trigger the activation of blood platelets, leading to thrombosis. If not addressed clinically, it can cause severe complications and fatal consequences as well. The current treatment regime for thrombosis is ...
14K prolactin derived 14-mer antiangiogenic peptide targets bradykinin-/nitric oxide-cGMP-dependent angiogenesis

Majumder, Syamantak (FEBS Press, 2024-09)

Over the past few decades, VEGF-targeted antiangiogenic therapy for cancers has gained increasing attention. Nevertheless, there are still several limitations such as the potential resistance mechanisms arising in cancer ...

Now showing items 1-20 of 702

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