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Dubey, Uma S.; Kapur, Suman (EJFA, 2016)

Camel milkis recognized for its therapeutic potential against many diseases. It is reported to have microbicidal and immuno stimulatory properties as it contains immunoactive proteins like lysozyme, lactoperoxidase and ...

Modeling the intracellular pathogen-immune interaction with cure rate

Dubey, Uma S.; Dubey, Balram (Elsiever, 2016-09)

Many common and emergent infectious diseases like Influenza, SARS, Hepatitis, Ebola etc. are caused by viral pathogens. These infections can be controlled or prevented by understanding the dynamics of pathogen-immune ...

Gene deleted live attenuated Leishmania vaccine candidates against visceral leishmaniasis elicit pro-inflammatory cytokines response in human PBMCs

Dubey, Uma S. (Nature, 2016)

Currently no effective vaccine is available for human visceral leishmaniasis(VL) caused by Leishmania donovani. Previously, we showed that centrin1 and p27gene deleted live attenuated Leishmania parasites (LdCen1−/− and ...

Epidemiology of breast cancer in Indian women

Dubey, Uma S. (Wiley, 2017-02-09)

Breast cancer has ranked number one cancer among Indian females with age adjusted rate as high as 25.8 per 100,000 women and mortality 12.7 per 100,000 women. Data reports from various latest national cancer registries ...

Modeling the role of acquired immune response and antiretroviral therapy in the dynamics of HIV infection

Dubey, Uma S.; Dubey, Balram (Elsiever, 2018-02)

This paper deals with the study of a virus dynamics model in order to get better insights into HIV infection within the body. The model incorporates therapeutic modalities such as reverse transcriptase inhibitors (RTIs) ...

Study on the effects of Cl and F doping in TiO2 powder synthesized by a sol-gel route for biomedical applications

Dubey, Uma S.; Roy, Banasri (Elsiever, 2019-11)

F- and Cl-doped (10 at%) TiO2 powders were prepared by a sol-gel route and calcined at different temperatures and for different times. X-ray diffraction, thermogravimetric- and differential-thermal analysis showed that ...

Research Journal of Pharmaceutical, Biological and Chemical Sciences

Dubey, Uma S. (RJPBCS, 2020)

α-lactalbumin-Oleic acid complex derived from milk is well known to have anti-cancer properties in many diverse mammalian species including humans, goats and cows. The objective of the current study is to see if α-lactalbumin ...

Quinoline Glycoconjugates as Potentially Anticancer and Anti-Inflammatory Agents: An Investigation Involving Synthesis, Biological Screening, and Dockin

Dubey, Uma S.; Sah, Ajay Kumar; Shukla, Paritosh (ECSP, 2020-08-20)

The present work is a preliminary report of synthesis of a series of targeted 4,6-O-ethylidene-β-D-glucopyranosylamine glycoconjugate quinoline 4-carboxylic acid derivatives followed by a quick evaluation of their ...

Modeling the dynamics of viral–host interaction during treatment of productively infected cells and free virus involving total immune response

Dubey, Uma S.; Dubey, Balram (VUP, 2021)

Virus dynamics models are useful in interpreting and predicting the change in viral load over the time and the effect of treatment in emerging viral infections like HIV/AIDS, hepatitis B virus (HBV). We propose a ...

Calcium chloride linked camel milk deried casein nanoparticles for the delivery of sorafenib in hepatocarcinoma cells

Dubey, Uma S. (TSP, 2021)

Sorafenib, a multikinase inhibitor used for the treatment of hepatocellular carcinoma, is limited by its low oral bioavailability. To overcome this drawback, we have developed novel camel milk casein-derived nanoparticles ...

Developing an Ex Vivo Model of Ischemia Using Early Chick-Embryo: A Model to Study Ischemia Related Angiogenesis

Majumder, Syamantak (Springer, 2012-06-19)

Ischemia created in the animals were long been used as a model to study ischemia mediated effects in vivo. Pathological angiogenesis is the key hallmark of various ischemic diseases where blood vessel formation was compromised ...

Use of Stem Cells to Block the Activation of Hepatic Stellate Cells in Diseased Liver

Majumder, Syamantak (Springer, 2014-11-12)

Liver is an important organ in vertebrates and performs major functions such as digestion, drug detoxification, and protein synthesis. Chronic liver fibrosis is a major threat to human life. The etiology of liver fibrosis ...

Regulation of Oxidative Stress by Nitric Oxide Defines Lung Development and Diseases

Majumder, Syamantak (Springer, 2019-11-24)

Development and maturation of the lung airways primarily take place in two different phases: first during embryonic days and second during postnatal days. During postnatal development, rapid angiogenesis and alveolarization ...

Activated pericyte attenuates endothelial functions: nitric oxide – cGMP rescues activated pericyte-associated endothelial dysfunctions

Majumder, Syamantak (CSP, 2007-11-23)

Hepatic stellate cells are liver-specific pericytes and exist in close proximity with endothelial cells. The activation of liver pericytes is intrinsic to liver pathogenesis, and leads to endothelial dysfunction, including ...

Dose dependent effects of cadmium on tumor angiogenesis

Majumder, Syamantak (Oncotargot, 2017)

Angiogenesis is crucial for tumor growth and metastasis. Cadmium (Cd) exposure is associated with elevated cancer risk and mortality. Such association is, at least in part, attributable to Cd-induced tumor angiogenesis. ...

Nitric oxide/cGMP protects endothelial cells from hypoxia-mediated leakiness

Majumder, Syamantak (Elsiever, 2008-03-17)

Leakiness of the endothelial bed is attributed to the over-perfusion of the pulmonary bed, which leads to high altitude pulmonary edema (HAPE). Inhalation of nitric oxide has been successfully employed to treat HAPE patients. ...

The Role of Calreticulin Transacetylase in the Activation of Human Platelet Nitrite Reductase by Polyphenolic Acetates

Majumder, Syamantak (J-Stage, 2009)

Our earlier investigations demonstrated the remarkable activation of cytochrome P-450 reductase and nitric oxide synthase by 7,8-diacetoxy-4-methylcoumarin, a model polyphenolic acetate by way of acetylation, catalyzed by ...

Cadmium attenuates bradykinin-driven nitric oxide production by interplaying with the localization pattern of endothelial nitric oxide synthase

Majumder, Syamantak (CSP, 2009-06-17)

Cadmium, a ubiquitous heavy metal, interferes with endothelial functions and angiogenesis. Bradykinin is a Ca-mobilizing soluble peptide that acts via nitric oxide to promote vasodilation and capillary permeability. The ...

Thalidomide attenuates nitric oxide-driven angiogenesis by interacting with soluble guanylyl cyclase

Majumder, Syamantak (Wiley, 2009-11-30)

Nitric oxide (NO) promotes angiogenesis by activating endothelial cells. Thalidomide arrests angiogenesis by interacting with the NO pathway, but its putative targets are not known. Here, we have attempted to identify these ...

Evaluation of the role of nitric oxide in acid sensing ion channel mediated cell death

Majumder, Syamantak (Elsiever, 2010-04-01)

Acid sensing ion channels (ASICs) are widely expressed in central and peripheral nervous system. They are involved in a variety of physiological and pathophysiological processes: synaptic transmission, learning and memory, ...

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Department of Biological Sciences: Recent submissions

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