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Therapeutic and toxicologic evaluation of anti-lipogenic agents in cancer cells compared with non-neoplastic cells

Deepa, P.R. (PMC, 2012)

Fatty acid synthase (FASN), a multi-enzyme complex, is involved in lipid biosynthesis. FASN is over-expressed in different types of cancers and is being widely investigated for its role in cancer progression, diagnosis and ...

Molecular deregulation induced by silencing of the high mobility group protein A2 gene in retinoblastoma cells

Deepa, P.R. (PMC, 2012)

To explore the molecular mechanisms deregulated by high mobility group protein A2 (HMGA2) gene silencing in retinoblastoma (RB) cells.

A Bio-mathematical Approach to Evaluate the Risk Burden of Hypertension and Hyperlipidemia in Diabetic Cardiovascular Disease

Deepa, P.R. (Scientific & Academic Publishing, 2012)

Cardiovascular disease (CVD) is a major cause of mortality in both developed and developing countries, owing to significant increase in the intake of high-energy foods, reduced physical activity, and an increase in ...

Microarray Analysis and Biochemical Correlations of Oxidative Stress Responsive Genes in Retinoblastoma

Deepa, P.R. (Taylor & Francis, 2012)

Oxidative stress, which refers to the biological damage caused by free radicals produced in excess of innate antioxidant defenses, is indicated in the ocular cancer retinoblastoma (RB). Here we have analysed the differential ...

Fatty Acid Synthase Inhibition Induces Differential Expression of Genes Involved in Apoptosis and Cell Proliferation in Ocular Cancer Cells

Deepa, P.R. (Taylor & Francis, 2013)

Fatty acid synthase (FASN), a lipogenic multienzyme complex, is overexpressed in the ocular cancer, retinoblastoma, and is strongly correlated with tumor invasion. Dietary nutrients are reported to exert anticancer effects ...

The Metabolic Advantage of Choline Lactate in Growth Media: An Experimental Analysis with Staphylococcus lentus

Deepa, P.R. (Springer, 2012)

The metabolic effectiveness of choline lactate in the growth media was investigated relative to conventional carbon source for growing Staphylococcus lentus, a bacterial strain commonly used in bioremediation of industrial ...

Biochemical changes accompanying apoptotic cell death in retinoblastoma cancer cells treated with lipogenic enzyme inhibitors

Deepa, P.R. (Elsiever, 2013)

Retinoblastoma (RB) is a malignant intra-ocular neoplasm that affects children (usually below the age of 5 years). In addition to conventional chemotherapy, novel therapeutic strategies that target metabolic pathways such ...

Molecular Insights on Post-chemotherapy Retinoblastoma by Microarray Gene Expression Analysis

Deepa, P.R. (Sage, 2013)

Management of Retinoblastoma (RB), a pediatric ocular cancer is limited by drug-resistance and drug-dosage related side effects during chemotherapy. Molecular de-regulation in post-chemotherapy RB tumors was investigated.

A molecular model of human Lysyl Oxidase (LOX) with optimal copper orientation in the catalytic cavity for induced fit docking studies with potential modulators

Deepa, P.R. (PMC, 2014)

Lysyl oxidase (LOX) is a copper dependent amine oxidase which catalyses the cross linking of collagen and elastin towards the maturation of extracellular matrix. The expression and activity of LOX is known to vary under ...

Integrated Analysis of Dysregulated miRNA-Gene Expression in HMGA2-Silenced Retinoblastoma Cells

Deepa, P.R. (Sage, 2014)

Retinoblastoma (RB) is a primary childhood eye cancer. HMGA2 shows promise as a molecule for targeted therapy. The involvement of miRNAs in genome-level molecular dys-regulation in HMGA2-silenced RB cells is poorly understood. ...

Comparative Modeling and Molecular Dynamics Simulation of Substrate Binding in Human Fatty Acid Synthase: Enoyl Reductase and β-Ketoacyl Reductase Catalytic Domains

Deepa, P.R. (Korea Genome Organization, 2015)

Fatty acid synthase (FASN, EC 2.3.1.85), is a multi-enzyme dimer complex that plays a critical role in lipogenesis. This lipogenic enzyme has gained importance beyond its physiological role due to its implications in several ...

Global Gene Deregulations in FASN Silenced Retinoblastoma Cancer Cells: Molecular and Clinico-Pathological Correlations

Deepa, P.R. (Wiley, 2015)

Activation of fatty acid synthase (FASN) enzyme in the de novo lipogenic pathway has been reported in various cancers including retinoblastoma (RB), a pediatric ocular cancer. The present study investigates lipogenesis-dependent ...

Computational and in vitro Investigation of miRNA-Gene Regulations in Retinoblastoma Pathogenesis: miRNA Mimics Strategy

Deepa, P.R. (Sage, 2015)

Retinoblastoma (RB), a primary pediatric intraocular tumor, arises from primitive retinal layers. Several novel molecular strategies are being developed for the clinical management of RB. miRNAs are known to regulate ...

Clinico-Pathological Association of Delineated miRNAs in Uveal Melanoma with Monosomy 3/Disomy 3 Chromosomal Aberrations

Deepa, P.R. (Plos One, 2016)

To correlate the differentially expressed miRNAs with clinico-pathological features in uveal melanoma (UM) tumors harbouring chromosomal 3 aberrations among South Asian Indian cohort.

Targeting HSP90/Survivin using a cell permeable structure based peptido-mimetic shepherdin in retinoblastoma

Deepa, P.R. (Elsiever, 2016)

Retinoblastoma (RB) is a childhood retinal malignancy. Effective therapeutic strategies are still being investigated in RB disease management. Here, the anti-cancer effect of shepherdin, a peptido-mimetic inhibiting heat ...

Effect of feeding strategies on inulinase production analyzed in a biocalorimeter

Deepa, P.R. (Elsiever, 2016)

Kluyveromyces marxianus exoinulinase production in shaker and bio reaction calorimeter has been studied. Biocalorimetric studies revealed enhanced inulinase production due to the linear and exponential feeding of sucrose. ...

In Silico Structure Prediction of Human Fatty Acid Synthase-Dehydratase: A Plausible Model for Understanding Active Site Interactions

Deepa, P.R. (Sage, 2016)

Fatty acid synthase (FASN, UniProt ID: P49327) is a multienzyme dimer complex that plays a critical role in lipogenesis. Consequently, this lipogenic enzyme has gained tremendous biomedical importance. The role of FASN and ...

Targeting HMGA2 in Retinoblastoma Cells in vitro Using the Aptamer Strategy

Deepa, P.R. (Karger, 2016)

High-mobility group A2 (HMGA2) protein regulates retinoblastoma (RB) cancer cell proliferation. Here, a stable phosphorothioate-modified HMGA2 aptamer was used to block HMGA2 protein function in RB cells. HMGA2-aptamer ...

Mathematical Modeling of Coronary Artery Disease (CAD): Analysis Reveals HbA1c and Total Cholesterol to be Significant Risk Predictors

Deepa, P.R.; Murali, Padma (Sage, 2017)

The increasing prevalence of CAD (Coronary Artery Disease) calls for early detection of risk factors and effective clinical management. The predictive potential of commonly estimated clinical variables on CAD incidence was ...

Comparative docking of dual conformations in human fatty acid synthase thioesterase domain reveals potential binding cavity for virtual screening of ligands

Deepa, P.R. (Taylor & Francis, 2017)

Human fatty acid synthase (hFASN), a homo dimeric lipogenic enzyme with seven catalytic domains, is an important clinical target in cancer, metabolic syndrome and infections. Here, molecular modelling and docking methods ...

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