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Isolation and characterization of bioactive lactoferrin from camel milk by novel pH-dependent method for large scale production

Dubey, Uma S. (Elsevier, 2022-12)

The present article exemplifies a novel method to isolate highly purified bioactive lactoferrin from camel milk. Cytotoxicity of lactoferrin against the Hela cells was used to evaluate its bioactivity. SDS-PAGE and LC-MS ...

Dual Role for Zn2+ in Maintaining Structural Integrity and Inducing DNA Sequence Specificity in a Promiscuous Endonuclease

Ghosh, Soumitra (Elsevier, 2007-11)

We describe two uncommon roles for Zn2+ in enzyme KpnI restriction endonuclease (REase). Among all of the REases studied, KpnI REase is unique in its DNA binding and cleavage characteristics. The enzyme is a poor discriminator ...

Moonlighting function of glutamate racemase from Mycobacterium tuberculosis: racemization and DNA gyrase inhibition are two independent activities of the enzyme

Ghosh, Soumitra (American Society for Microbiology, 2008-09)

Glutamate racemase (MurI) provides d-glutamate, a key building block in the peptidoglycan of the bacterial cell wall. Besides having a crucial role in cell wall biosynthesis, MurI proteins from some bacteria have been shown ...

Regulation of Lipid Biosynthesis, Sliding Motility, and Biofilm Formation by a Membrane-Anchored Nucleoid-Associated Protein of Mycobacterium tuberculosis

Ghosh, Soumitra (American Society for Microbiology, 2013-03)

Bacteria use a number of small basic proteins for organization and compaction of their genomes. By their interaction with DNA, these nucleoid-associated proteins (NAPs) also influence gene expression. Rv3852, a NAP of ...

HupB, a Nucleoid-Associated Protein of Mycobacterium tuberculosis, Is Modified by Serine/Threonine Protein Kinases In Vivo

Ghosh, Soumitra (American Society for Microbiology, 2014-06)

HU, a widely conserved bacterial histone-like protein, regulates many genes, including those involved in stress response and virulence. Whereas ample data are available on HU-DNA communication, the knowledge on how HU ...

Direct regulation of topoisomerase activity by a nucleoid-associated protein

Ghosh, Soumitra (OUP, 2014-09)

The topological homeostasis of bacterial chromosomes is maintained by the balance between compaction and the topological organization of genomes. Two classes of proteins play major roles in chromosome organization: the ...

Targeting Mycobacterium tuberculosis nucleoid-associated protein HU with structure-based inhibitors

Ghosh, Soumitra (Springer Nature, 2014-06)

The nucleoid-associated protein HU plays an important role in maintenance of chromosomal architecture and in global regulation of DNA transactions in bacteria. Although HU is essential for growth in Mycobacterium tuberculosis ...

Transcriptional regulation of topology modulators and transcription regulators of Mycobacterium tuberculosis

Ghosh, Soumitra (Elsevier, 2016-07)

Mycobacterium tuberculosis (Mtb) is a formidable pathogen which has the ability to survive the hostile environment of the host by evading the host defense system. The re-configuration of its transcriptional and metabolic ...

Lysine acetylation of the Mycobacterium tuberculosis HU protein modulates its DNA binding and genome organization

Ghosh, Soumitra (Wiley, 2016-01)

Nucleoid-associated protein HU, a conserved protein across eubacteria is necessary for maintaining the nucleoid organization and global regulation of gene expression. Mycobacterium tuberculosis HU (MtHU) is distinct from ...

A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis

Ghosh, Soumitra (Elsevier, 2017-11)

Till recently, knowledge about epigenetic regulation in bacterial world confined largely to DNA methylation. Lysine acetylation/deacetylation of histones is a major contributor for chromatin dynamics in eukaryotes. However, ...

Convergent roles of ATF3 and CSL in chromatin control of cancer-associated fibroblast activation

Ghosh, Soumitra (JEM, 2017)

Cancer-associated fibroblasts (CAFs) are important for tumor initiation and promotion. CSL, a transcriptional repressor and Notch mediator, suppresses CAF activation. Like CSL, ATF3, a stress-responsive transcriptional ...

Androgen receptor functions as transcriptional repressor of cancer-associated fibroblast activation

Ghosh, Soumitra (JCI, 2018-11)

The aging-associated increase of cancer risk is linked with stromal fibroblast senescence and concomitant cancer-associated fibroblast (CAF) activation. Surprisingly little is known about the role of androgen receptor (AR) ...

Physical and functional interaction between nucleoid-associated proteins HU and Lsr2 of Mycobacterium tuberculosis: altered DNA binding and gene regulation

Ghosh, Soumitra (Wiley, 2019-01)

Nucleoid-associated proteins (NAPs) in bacteria contribute to key activities such as DNA compaction, chromosome organization and regulation of gene expression. HU and Lsr2 are two principal NAPs in Mycobacterium tuberculosis ...

CSL controls telomere maintenance and genome stability in human dermal fibroblasts

Ghosh, Soumitra (EPFL, 2019-08)

Genomic instability is a hallmark of cancer. Whether it also occurs in Cancer Associated Fibroblasts (CAFs) remains to be carefully investigated. Loss of CSL/RBP-J kappa, the effector of canonical NOTCH signaling with ...

Sustained androgen receptor signaling is a determinant of melanoma cell growth potential and tumorigenesis

Ghosh, Soumitra (Journal of Experimental Medicine, 2020-10)

Melanoma susceptibility differs significantly in male versus female populations. Low levels of androgen receptor (AR) in melanocytes of the two sexes are accompanied by heterogeneous expression at various stages of the ...

Androgen receptor is a determinant of melanoma targeted drug resistance

Ghosh, Soumitra (Springer Nature, 2023-10)

Melanoma provides a primary benchmark for targeted drug therapy. Most melanomas with BRAFV600 mutations regress in response to BRAF/MEK inhibitors (BRAFi/MEKi). However, nearly all relapse within the first two years, and ...

ANKRD1 is a mesenchymal-specific driver of cancer-associated fibroblast activation bridging androgen receptor loss to AP-1 activation

Ghosh, Soumitra (Springer Nature, 2024-02)

There are significant commonalities among several pathologies involving fibroblasts, ranging from auto-immune diseases to fibrosis and cancer. Early steps in cancer development and progression are closely linked to fibroblast ...

Nuclear lamin A/C phosphorylation by loss of Androgen Receptor is a global determinant of cancer-associated fibroblast activation

Ghosh, Soumitra (2023)

Alterations of nuclear structure and function, and associated impact on gene transcription, are a hallmark of cancer cells. Little is known of these alterations in Cancer-Associated Fibroblasts (CAFs), a key component of ...

Expression and functional analysis of rice genes involved in reproductive development and stress response

Sharma, Rita (World Scientific, 2007)

The rice genome sequenced and annotated by the IRGSP has identified 37,544 protein-coding genes. In an effort to identify genes encoding transcription factors and signal transduction components, more than 7,000 genes ...

Role of phytohormones in regulating agronomically important seed traits in crop plants

Sharma, Rita (Elsevier, 2023)

Seed development is a complex process that commences after double fertilization. Both forward and reverse genetic studies have revealed the critical roles of phytohormones in regulating seed development and the associated ...

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