The ‘capture’ of proteins by small molecules via irreversible cross-linking mediated by photo-irradiation is of interest in the field of proteomics (for reviews see ref. 1). The technique has the potential for profiling ...

Chemoselective modification of complex biomolecules has become a cornerstone of chemical biology. Despite the exciting developments of the past two decades, the demand for new chemoselective reactions with unique abilities, ...

In the last two decades, unnatural amino acid (UAA) mutagenesis has emerged as a powerful new method to probe and engineer protein structure and function. This technology enables precise incorporation of a rapidly expanding ...

Development of new strategies for C–C bond formation remains in the forefront of organic synthesis. The base-mediated rearrangement of bis-propargyl sulfones via bis-allenes generated in situ, now known as the Garratt–Braverman ...

The Label-Assisted Laser Desorption/Ionization (LA-LDI) technique has recently been applied to the detection of small molecules through a Time of Flight (TOF) mass spectrometric measurement. By excluding the external matrix, ...

The MALDI-based mass spectrometry, over the last three decades, has become an important analytical tool. It is a gentle ionization technique, usually applicable to detect and characterize analytes with high molecular weights ...

In this study, we demonstrate the feasibility of expanding the genetic code of Escherichia coli using its own tryptophanyl–tRNA synthetase and tRNA (TrpRS–tRNATrp) pair. This was made possible by first functionally replacing ...

An external matrix-free LDI technique for selective detection zinc ion is described. An internal polyaromatic label helped desorption cum ionization processes. The method is free of cross-interference which as often faced ...

Chemoselective labeling of a 5-hydroxytryptophan residue, which can be site-specifically incorporated into proteins through nonsense suppression, generates a highly chromophoric biarylazo group that is a potent fluorescence ...

A comparative study of the various methodologies to construct bicyclic γ-lactams is reported. Thus RhII-catalyzed decomposition of 2-pyrrolidone and pyrrolidine derived diazomalonates were attempted to synthesize fused ...