• Design and synthesis of non-hydroxamate lipophilic inhibitors of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR): in silico, in vitro and antibacterial studies 

  Sundriyal, Sandeep (RSC, 2024-08)

  1-Deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is a key enzyme of the 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway operating in several pathogens, including Mycobacterium and Plasmodium. Since a DXR homologue ...
• S-nitrosylation of EZH2 at C329 and C700 interplay with PRC2 complex assembly, methyltransferase activity, and EZH2 stability to regulate endothelial functions 

  Sundriyal, Sandeep; Chowdhury, Shibasish; Majumder, Syamantak (2024)

  Nitric oxide (NO), a versatile bio-active molecule modulates cellular function through diverse mechanisms including S-nitrosylation of proteins. However, the role of this post-translational modification in regulating ...
• Introduction to health informatics (hi): enhancing healthcare through information technology 

  Sundriyal, Sandeep (Springer, 2024)

  Health informatics (HI) is an interdisciplinary field that integrates data science, information technology, and healthcare to enhance the administration and delivery of healthcare services. It includes the storage, ...
• Environmental sustainability and its impact on public health 

  Sundriyal, Sandeep (Springer, 2024-09)

  This book chapter provides a comprehensive review of the relationship between environmental sustainability and public health. It explores the various environmental factors that affect public health, discusses the pathways ...
• Basic nitrogen (BaN): a ‘privileged element’ in medicinal chemistry 

  Sundriyal, Sandeep (Taylor & Francis, 2024-10)

  Medicinal chemists continuously search for small molecules with ideal pharmacokinetic and pharmacodynamic (PKPD) profiles. This quest has resulted in several efforts to understand and define ‘druglikeness’ or ‘drug-like ...
• Unlocking the immunomodulatory potential of rosmarinic acid isolated from punica granatum l. Using bioactivity-guided approach: in silico, in vitro, and in vivo approaches 

  Sundriyal, Sandeep (Bentham Science, 2024-11)

  Punica granatum L. is well-known for its multifaceted therapeutic potential, including anti-inflammatory and immunomodulatory activities. Aim: This study aimed to characterize an immunomodulatory compound isolated from ...
• Multicomponent reactions (MCRs) yielding medicinally relevant rings: a recent update and chemical space analysis of the scaffolds 

  Sundriyal, Sandeep (RSC, 2025-01)

  In this review we have compiled multicomponent reactions (MCRs) that produce cyclic structures. We have covered articles reported since 2019 to showcase the recent advances in this area. In contrast to other available ...
• Design, synthesis and in vitro evaluation of primaquine and diaminoquinazoline hybrid molecules against the malaria parasite 

  Sundriyal, Sandeep (Wiley, 2025-01)

  In this study, we built on the known inhibitory potential of diaminoquinazolines (DAQs) against different stages of Plasmodium development and designed a convenient two-step synthesis to combine DAQ with primaquine (PQ) ...
• Identification of synthetically tractable MERS-CoV main protease inhibitors using structure-based virtual screening and molecular dynamics potential of mean force (PMF) calculations 

  Sundriyal, Sandeep (Taylor & Francis, 2023-11)

  The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is a potentially lethal infection that presents a substantial threat to health, especially in Middle East nations. Given that no FDA-approved specific therapy for ...
• Development and experimental validation of a machine learning model for the prediction of new antimalarials 

  Sundriyal, Sandeep (Springer, 2025-01)

  A large set of antimalarial molecules (N ~ 15k) was employed from ChEMBL to build a robust random forest (RF) model for the prediction of antiplasmodial activity. Rather than depending on high throughput screening (HTS) ...
• Resorption potential of endoflas powder with curcumin gel against endoflas for pulpectomy in primary mandibular molars: a one-year follow-up evidence-based case reports 

  Mahesh, Radhakrishnan (Springer Nature, 2024-06)

  Pediatric endodontics in the primary teeth is chemomechanical due to the difficulties encountered in cleaning and shaping the root canals having complex anatomical configurations. Not only are obturating materials having ...
• Converged avenues: depression and Alzheimer’s disease– shared pathophysiology and novel therapeutics 

  Mahesh, Radhakrishnan (Springer, 2024-01)

  Depression, a highly prevalent disorder affecting over 280 million people worldwide, is comorbid with many neurological disorders, particularly Alzheimer’s disease (AD). Depression and AD share overlapping pathophysiology, ...
• Significance of LncRNAs in AKI-to-CKD transition: a therapeutic and diagnostic viewpoint 

  Gaikwad, Anil Bhanudas; Majumder, Syamantak (Elsevier, 2024-04)

  Acute kidney injury to chronic kidney disease (AKI-to-CKD) transition is a complex intermingling of characteristics of both AKI and CKD. Pathophysiologically, the transition lasts seven days after the AKI episode and ...
• Immunosuppressants against acute kidney injury: what to prefer or to avoid? 

  Gaikwad, Anil Bhanudas (Taylor & Francis, 2024-03)

  Acute kidney injury (AKI) is a critical global health issue associated with high mortality rates, particularly in patients undergoing renal transplants and major surgeries. These individuals often receive immunosuppressants ...
• A structure-based pharmacophore modelling approach to identify and design new neprilysin (NEP) inhibitors: An in silico-based investigation 

  Gaikwad, Anil Bhanudas (Elsevier, 2024-06)

  Neutral endopeptidase or neprilysin (NEP) cleaves the natriuretic peptides, bradykinin, endothelin, angiotensin II, amyloid β protein, substance P, etc., thus modulating their effects on heart, kidney, and other organs. ...
• Targeting polo-like kinase 1 to treat kidney diseases 

  Gaikwad, Anil Bhanudas (Wiley, 2024-07)

  Globally, ∼850 million individuals suffer from some form of kidney disease. This staggering figure underscores the importance of continued research and innovation in the field of nephrology to develop effective treatments ...
• Natriuretic peptide system in hypertension: Current understandings of its regulation, targeted therapies and future challenges 

  Gaikwad, Anil Bhanudas (Elsevier, 2024-08)

  The natriuretic peptide system (NPS) is the key driving force of the heart's endocrine function. Recent developments in NPS-targeted therapies have been found promising and effective against cardiovascular diseases, including ...
• Apelinergic system in acute kidney injury: mechanistic insights and therapeutic potential 

  Gaikwad, Anil Bhanudas (Elsevier, 2024-11)

  Acute kidney injury (AKI) has emerged as a global health crisis, surpassing mortality rates associated with several cancers and heart failure. The lack of effective therapies, coupled with challenges in diagnosis and the ...
• Acyl-coa synthetase long-chain isoenzymes in kidney diseases: mechanistic insights and therapeutic implications 

  Gaikwad, Anil Bhanudas (Wiley, 2024-08)

  Long-chain acyl-CoA synthetases (ACSLs) are pivotal enzymes in fatty acid metabolism, essential for maintaining cellular homeostasis and energy production. Recent research has uncovered their significant involvement in the ...
• Molecular insights into P2X signalling cascades in acute kidney injury 

  Gaikwad, Anil Bhanudas (Springer, 2024-01)

  Acute kidney injury (AKI) is a critical health issue with high mortality and morbidity rates in hospitalized individuals. The complex pathophysiology and underlying health conditions further complicate AKI management. ...

View more