Department of Pharmacy: Recent submissions

Now showing items 201-220 of 772

Improved skin-permeated diclofenac-loaded lyotropic liquid crystal nanoparticles: QbD-driven industrial feasible process and assessment of skin deposition

Singhvi, Gautam (Taylor & Francis, 2020-10)

The purpose of the present study was to optimise diclofenac diethylamine-loaded liquid crystal nanoparticles (LCNPs) using the principles of quality by design. Based on risk assessment, the effect of various formulation ...
Solid lipid nanocarriers embedded hydrogel for topical delivery of apremilast: In-vitro, ex-vivo, dermatopharmacokinetic and anti-psoriatic evaluation

Singhvi, Gautam; Roy, Aniruddha (Elsevier, 2021-06)

The present work aimed to develop topical solid lipid nanocarriers (SLN) loaded hydrogel of apremilast (API) for psoriasis therapy to minimize the systemic adverse effects. The quality by design approach was implemented ...
Chitosan-based microneedles as a potential platform for drug delivery through the skin: Trends and regulatory aspects

Singhvi, Gautam (Elsevier, 2021-08)

Microneedles (MNs) fabrication using chitosan has gained significant interest due to its ability of film-forming, biodegradability, and biocompatibility, making it suitable for topical and transdermal drug delivery. The ...
Design and dermatokinetic evaluation of Apremilast loaded nanostructured lipid carriers embedded gel for topical delivery: A potential approach for improved permeation and prolong skin deposition

Singhvi, Gautam; Roy, Aniruddha (Elsevier, 2021-10)

The present study aimed to develop Apremilast loaded nanostructured lipid carriers (NLCs) for topical delivery to overcome the limitations of oral therapy and increase the efficacy. Apremilast loaded NLCs were prepared by ...
CD44 receptor-targeted novel drug delivery strategies for rheumatoid arthritis therapy

Singhvi, Gautam (Taylor & Francis, 2021-07)

Rheumatoid arthritis (RA) is a chronic systemic inflammatory condition that mainly affects the lining of the synovial joints. It can progressively cause disability and even premature death. Moreover, it is associated with ...
Revisiting techniques to evaluate drug permeation through skin

Singhvi, Gautam (Taylor & Francis, 2021-12)

Investigating the transportation of a drug molecule through various layers of skin and determining the amount of drug retention in skin layers is of prime importance in transdermal and topical drug delivery. The information ...
Exploring the affluent potential of glyceryl mono oleate – myristol liquid crystal nanoparticles mediated localized topical delivery of Tofacitinib: Study of systematic QbD, skin deposition and dermal pharmacokinetics assessment

Singhvi, Gautam (Elsevier, 2022-01)

This study aimed to design and characterize Tofacitinib (TF)-loaded lyotropic liquid crystalline nanoparticles (TF-LCNP) gel using quality by design-driven approach to enhance the skin delivery of TF. The present work ...
The Hedgehog pathway and its inhibitors: Emerging therapeutic approaches for basal cell carcinoma

Singhvi, Gautam (Elsevier, 2022-04)

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer (NMSC). Although surgery is the first-line treatment, BCC can lead in some cases, to a metastatic or advanced form, requiring targeted combination ...
Emerging trends in microneedle-based drug delivery strategies for the treatment of rheumatoid arthritis

Singhvi, Gautam (Taylor & Francis, 2022-04)

The current drug therapies for treating rheumatoid arthritis (RA) include nonsteroidal anti-inflammatory drugs, disease-modifying antirheumatic drugs, or biological products designed to mitigate the symptoms of the disease. ...
Quality by design assisted optimization of temozolomide loaded PEGylated lyotropic liquid crystals: Investigating various formulation and process variables along with in-vitro characterization

Singhvi, Gautam; Roy, Aniruddha (Elsevier, 2022-04)

Temozolomide (TMZ) is approved for the treatment of glioblastoma. The objective of the present study was to develop and characterize TMZ loaded lyotropic liquid crystals (LLCs) for intravenous delivery. Various formulation ...
Dermatokinetic assessment of luliconazole-loaded nanostructured lipid carriers (NLCs) for topical delivery: QbD-driven design, optimization, and in vitro and ex vivo evaluations

Singhvi, Gautam (Springer, 2021-04)

The present study is concerned with the QbD-based design and development of luliconazole-loaded nanostructured lipid carriers (NLCs) hydrogel for enhanced skin retention and permeation. The NLCs formulation was optimized ...
Insight on updates in polysaccharides for ocular drug delivery

Singhvi, Gautam (Elsevier, 2022-12)

Ocular drug delivery is a significantly challenging task due to the presence of various anatomical and physiological barriers in the eye. Naturally available polysaccharides, when used as drug vehicles provide increased ...
An insight into photodynamic therapy towards treating major dermatological conditions

Singhvi, Gautam (2022-10)

Photodynamic therapy (PDT), as the name suggests is a light-based, non-invasive therapeutic treatment method that has garnered immense interest in the recent past for its efficacy in treating several pathological conditions. ...
Tailoring the multi-functional properties of phospholipids for simple to complex self-assemblies

Singhvi, Gautam (Elsevier, 2022-09)

The unique interfacial properties, huge diversity, and biocompatible nature of phospholipids make them an attractive pharmaceutical excipient. The amphiphilic nature of these molecules offers them the property to self-assemble ...
Insight into the pivotal role of signaling pathways in psoriasis pathogenesis, potential therapeutic molecules and drug delivery approaches

Singhvi, Gautam (Elsevier, 2023-02)

Psoriasis is a multifactorial chronic autoimmune skin disorder, the exact cause of which is still under investigation. It is classified into different types displaying various histopathological features such as hyperproliferation, ...
Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

Singhvi, Gautam (ACS, 2022-12)

Nanocarriers have the utmost significance for advancements in drug delivery and nanomedicine technology. They are classified as polymer-based nanocarriers, lipid-based nanocarriers, viral nanoparticles, or inorganic ...
Exploring microfluidics and membrane extrusion for the formulation of temozolomide-loaded liposomes: investigating the effect of formulation and process variables

Singhvi, Gautam (Taylor & Francis, 2022-11)

Liposomes have gained much attention in drug delivery since the entry of liposomal Doxorubicin (Doxil®) into the market. Liposomes can entrap lipophilic, hydrophilic as well as amphiphilic drug molecules due to their ...
Hyaluronic acid-coated proglycosomes for topical delivery of tofacitinib in rheumatoid arthritis condition: Formulation design, in vitro, ex vivo characterization, and in vivo efficacy studies

Singhvi, Gautam (Elsevier, 2023-01)

Tofacitinib (TF) is a selective oral jakanib approved by the USFDA for the treatment of rheumatoid arthritis (RA). To overcome the adverse effects of orally administered TF, topical delivery can be a suitable choice. The ...
Immunocyte Derived Exosomes: Insight into the Potential Chemo-immunotherapeutic Nanocarrier Targeting the Tumor Microenvironment

Mittal, Anupama (ACS, 2022-12)

“Cancer” is a dreadful immune-pathological condition that is characterized by anti-inflammatory and tumorigenic responses, elicited by the infiltrating immune cells in the vicinity of an uncontrollably proliferative tumor ...
Pramlintide an Adjunct to Insulin Therapy: Challenges and Recent Progress in Delivery

Mittal, Anupama; Chitkara, Deepak (ASPET, 2024-01)

Dysregulation of various glucoregulatory hormones lead to failure of insulin monotherapy in patients with diabetes mellitus due to various reasons, including severe hypoglycemia, glycemic hypervariability, and an increased ...

Now showing items 201-220 of 772

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