β-Amyloid (Aβ) peptide is a characteristic feature of Alzheimer’s disease (AD) and accumulation of Aβ is associated with loss of synaptic plasticity and neuronal cell death. Aggregation of Aβ initiates numerous molecular ...

This study focuses on exploring the role of sensory cation channel Transient Receptor Potential channel subfamily Vanilloid 1 (TRPV1) in gut health, specifically mucus production and microflora profile in gut. We employed ...

Finger millet (FM) and kodo millet (KM) are known for their multiple health benefits. Several studies have indicated the antioxidant and hypoglycemic potential of polyphenol rich extracts (PREs) from them. However, the ...

Transient receptor potential ankyrin 1 (TRPA1) channel is a calcium permeable, non-selective cation channel, expressed in the sensory neurons and non-neuronal cells of different tissues. Initially studied for its role in ...

Short-chain fatty acids (SCFAs), metabolites of colonic bacterial fermentation of complex carbohydrates, are closely related to the release of gut hormones. In this study, we examined the involvement of transient receptor ...

In the current scenario of COVID-19 outbreak whereby the virus spreads through fomites and aerosols, there has been a huge increase in the use of soaps, sanitizers and personal protective equipment’s (PPEs) which in turn ...

The term “dietary supplement” defines a comprehensive and diverse category of products that are essential to our health but are absent or insufficient in the diet and may be needed to take separately; requirement of dietary ...

Synthesis of AzaGly-appended peptidomimetics with improved biological and biochemical properties. Robust synthesis of azapeptide on solid support is demonstrated without noticeable hydantoin formation. The azapeptide derived ...

Tumor associated macrophages (TAMs), represent a major subpopulation of tumor infiltrating immune cells. These alternatively activated M2-polarized macrophages are well known for their pro-tumor functions. Owing to their ...

Augmented reactive oxygen species levels consequential to functional alteration of key mitochondrial attributes contribute to carcinogenesis, either directly via oxidative DNA damage infliction or indirectly via activation ...