Department of Pharmacy: Recent submissions

Now showing items 361-380 of 772

Design, Synthesis, Molecular Modelling and in Vitro Evaluation of Indolyl Ketohydrazide-Hydrazone Analogs as Potential Pancreatic Lipase Inhibitors

Paul, Atish Tulshiram (Wiley, 2023-08)

Inhibition of Pancreatic lipase (PL) is considered to be a promising target for the management of obesity, owing to its crucial role in the digestion of dietary triglycerides. A series of 31 indolyl ketohydrazide-hydrazone ...
Synthesis of amide warhead containing coumarin derivatives as potential pancreatic lipase inhibitors: in silico and in vitro evaluation for obesity treatment

Paul, Atish Tulshiram (Springer, 2023-07)

A series of coumarin-3-carboxamide analogues has been designed, synthesized and assessed for their ability to inhibit pancreatic lipase (PL). Amongst all the synthesized analogues 5q, 5k and 5c exhibited potential PL ...
Chromone-3-acrylic acid ester analogues: Design, synthesis and biological evaluation as potential pancreatic lipase inhibitors

Paul, Atish Tulshiram (Elsevier, 2023-12)

A novel series of 21 chromone-3-acrylic acid ester analogues (5aa-5cm) were designed, synthesized and evaluated for PL inhibitory activity. The molecular docking study indicate that all the designed chromone analogues have ...
Impact of quercetin on pharmacokinetics of quetiapine: insights from in-vivo studies in wistar rats

Paul, Atish Tulshiram (Taylor & Francis, 2020-07)

Quercetin (QCN) is commonly used in high doses as a dietary supplement for weight loss. Psychotic patients are at greater risk of developing obesity than the general population. The present study was designed to ...
Plant-Associated Endophytic Fungi and Its Secondary Metabolites Against Drug-Resistant Pathogenic Microbes

Paul, Atish Tulshiram; Jindal, Anil B. (Springer, 2022-01)

Antimicrobial resistance (AMR) is now one of the major concern in the public health globally, as it is increasing the cost of the treatment as well as time of hospitalization. The resistant microbes like bacteria, fungi, ...
Antimicrobial Resistance Underlying Mechanisms and Therapeutic Approaches

Paul, Atish Tulshiram (Springer, 2022)

Describes the mechanisms of AMR in hospital settings, agriculture, livestock and other environments
Molecular modelling, synthesis and in vitro evaluation of quinazolinone hybrid analogues as potential pancreatic lipase inhibitors

Paul, Atish Tulshiram (Taylor & Francis, 2022-11)

Obesity is a multifactorial metabolic disorder, growing in an alarming rate across the world. Amongst the numerous targets explored for obesity management, inhibition of pancreatic lipase (PL) is considered as one of the ...
Lupane Analogue from Bark of Pithecellobium dulce and in vitro α-Glucosidase and α-Amylase Enzyme Inhibition Assay of Extract for Potential Antidiabetic Activity

Paul, Atish Tulshiram (Springer, 2016)

Pithecellobium dulce (Roxb.) Benth. (Leguminosae) is an evergreen plant widely distributed in greater parts of India and is also found in Southeast Asia [1–3]. Many studies have been carried out on P. dulce with significant ...
Mechanistically acting anti-obesity compositions/formulations of natural origin: a patent review (2010-2021)

Paul, Atish Tulshiram (Taylor & Francis, 2022)

Current health trends indicate that the rate of incidence of obesity has risen considerably. According to the World Health Organization (WHO) report 2017, the issue of obesity has grown to an epidemic proportion, with over ...
PCB-77 biodegradation potential of biosurfactant producing bacterial isolates recovered from contaminated soil

Paul, Atish Tulshiram; Jha, Prabhat Nath (Frontiers, 2022-09)

Polychlorinated biphenyls (PCBs) are persistent organic pollutants widely distributed in the environment and possess deleterious health effects. The main objective of the study was to obtain bacterial isolates from ...
Synthesis, molecular modelling, in vitro and in vivo evaluation of conophylline inspired novel benzyloxy substituted indole glyoxylamides as potent pancreatic lipase inhibitors

Paul, Atish Tulshiram (Taylor & Francis, 2021-05)

Pancreatic lipase is a digestive enzyme involved in the hydrolysis of dietary fats. Orlistat, a potent pancreatic lipase inhibitor, is widely prescribed for long-term obesity treatment. Nevertheless, orlistat is reported ...
Physicochemical standardization, HPTLC profiling, and biological evaluation of Aśvagandhādyariṣṭa: A comparative study of three famous commercial brands

Paul, Atish Tulshiram (PMC, 2014)

Aśvagandhādyariṣṭa is a polyherbal formulation that is available commercially as an over the counter drug. There are three famous brands that are available in the market. However, there are no comparative reports on the ...
Unanticipated Cleavage of 2-Nitrophenyl-Substituted N-Formyl Pyrazolines under Bechamp Conditions: Unveiling the Synthesis of 2-Aryl Quinolines and Their Mechanistic Exploration via DFT Studies

Paul, Atish Tulshiram (ACS, 2018-12)

We herein report for the first time an unusual decomposition of 2-nitrophenyl-substituted N-formyl pyrazolines under Bechamp reduction condition employed to yield 2-aryl quinolines exclusively instead of pyrazolo[1,5-c]q ...
Rapid and cost-effective LC–MS/MS method for determination of hydroxycitric acid in plasma: Application in the determination of pharmacokinetics in commercial Garcinia preparations

Paul, Atish Tulshiram (Wiley, 2020-05)

Garcinia cambogia is one of the most commonly used anti-obesity dietary supplements, and hydroxycitric acid (HCA) is a major constituent in the commercial preparations of Garcinia. High doses of HCA are often consumed ...
Nanotechnology Based Delivery of Nutraceuticals

Paul, Atish Tulshiram; Jindal, Anil B. (Springer, 2018-11)

With the growing worldwide population, there is increase in prevalence of various diseases like cancer (0.338%), hyperlipidemia (39%), hypertension (44.5%), infectious disease (17 million/ annum), diabetes (18.4%), obesity ...
Design, synthesis, evaluation, and molecular modeling studies of indolyl oxoacetamides as potential pancreatic lipase inhibitors

Paul, Atish Tulshiram (Wiley, 2020-06)

A series of indolyl oxoacetamide analogs was synthesized, characterized, and evaluated for their pancreatic lipase inhibitory activity using porcine pancreatic lipase (type II) and 4-nitrophenyl butyrate. Compound 8d ...
Preparation and Evaluation of Quinapyramine Sulphate-Docusate Sodium Ionic Complex Loaded Lipidic Nanoparticles and Its Scale Up Using Geometric Similarity Principle

Paul, Atish Tulshiram; Jindal, Anil B. (Elsevier, 2021-05)

The objective of the present work is to prepare and evaluate ionically complexed Quinapyramine sulphate (QS) loaded lipid nanoparticles and its scale up using geometric similarity principle. Docusate sodium (DS), at a molar ...
Optimisation of an extraction conditions for Rumex nepalensis anthraquinones and its correlation with pancreatic lipase inhibitory activity

Paul, Atish Tulshiram (Elsevier, 2020-09)

Rumex nepalensis Spreng. (Polygonaceae) is an edible plant rich in anthraquinones, that significantly inhibits Pancreatic Lipase (PL), a key enzyme in the dietary fat digestion. The effectiveness of Ultrasonic Assisted ...
Diabetic Complications: A Natural Product Perspective

Paul, Atish Tulshiram (Bentham Science, 2017)

Diabetes is a chronic disease that affects over 400 million people globally. With 5.5% increase in diabetes related deaths in 2010, as compared to the 2007 and World Health Organisation's projection of diabetes as the 7th ...
Design, synthesis, biological evaluation and molecular modelling studies of oxoacetamide warhead containing indole-quinazolinone based novel hybrid analogues as potential pancreatic lipase inhibitors

Paul, Atish Tulshiram (RSC, 2022-05)

A novel series of indolyl oxoacetamide-quinazolinone hybrid analogues (9aa–9df) were designed, synthesized, and evaluated for their in vitro pancreatic lipase (PL) inhibitory potential which may lead to efficient anti-obesity ...

Now showing items 361-380 of 772

Search DSpace

Advanced Search

Browse

All of DSpace
This Collection
- By Issue Date
- Authors
- Titles
- Subjects

Recently added

Department of Pharmacy: Recent submissions

Search DSpace

Browse

All of DSpace

This Collection

My Account