Department of Pharmacy: Recent submissions

Now showing items 381-400 of 772

Development and validation of a new HPTLC method for quantification of conophylline in Tabernaemontana divaricata samples obtained from different seasons and extraction techniques: Insights into variation of pancreatic lipase inhibitory activity

Paul, Atish Tulshiram (Elsevier, 2018-01)

Tabernaemontana divaricata (L.) R. Br. Ex Roem. & Schult Apocynaceae) is an important indole alkaloid rich Indian medicinal plant with conophylline being a potential lead in the treatment of diabetes mellitus and obesity. ...
Design, synthesis, biological evaluation and molecular modelling studies of conophylline inspired novel indolyl oxoacetamides as potent pancreatic lipase inhibitors

Paul, Atish Tulshiram (RSC, 2020-06)

A novel series of 21 indolyl oxoacetamide analogues was designed based on the natural product lead conophylline, and evaluated for their pancreatic lipase inhibitory activity using porcine pancreatic lipase (Type II). ...
Investigation of synergistic potential of green tea polyphenols and orlistat combinations using pancreatic lipase assay-based synergy directed fractionation strategy

Paul, Atish Tulshiram (Elsevier, 2020-12)

The present study investigated the synergistic potential of methanol extract/fractions of Camellia sinensis (L.) Kuntze (CSM) leaves and orlistat on inhibition of Pancreatic Lipase (PL). Since PL is responsible for 50–70% ...
Design, synthesis and biological evaluation of N-substituted indole-thiazolidinedione analogues as potential pancreatic lipase inhibitors

Paul, Atish Tulshiram (Wiley, 2021-04)

Pancreatic Lipase (PL) is a key enzyme responsible for the digestion of 50%–70% of dietary triglycerides, hence its inhibition is considered as a viable approach for the management of obesity. A series of indole-TZD hybrid ...
Development and validation of a new HPTLC-HRMS method for the quantification of a potent pancreatic lipase inhibitory lead Echitamine from Alstonia scholaris

Paul, Atish Tulshiram (Taylor & Francis, 2019-12)

Alstonia scholaris is an important indole alkaloid rich medicinal plant with diverse pharmacological activity. To understand the effect of extraction techniques, the stem bark sample of A. scholaris was subjected to ...
Natural Products-Based Pancreatic Lipase Inhibitors for Obesity Treatment

Paul, Atish Tulshiram (Springer, 2019-09)

Obesity is a multifactorial metabolic disorder, majorly caused due to high-fat diet associated with decline in physical activity. Recent decades have seen a rapid upsurge in the obese population with over 650 million obese ...
Evaluation of biphenyl- and polychlorinated-biphenyl (PCB) degrading Rhodococcus sp. MAPN-1 on growth of Morus alba by pot study

Paul, Atish Tulshiram; Jha, Prabhat Nath (Taylor & Francis, 2020-06)

This study focused on isolation of bacteria with biphenyl/polychlorinated biphenyl (PCB) degrading ability from the rhizosphere of Morus alba (mulberry plant). Repetitive enrichment of rhizospheric soil samples with biphenyl ...
Evaluation of Proinflammatory Cytokine Pathway Inhibitors for p38 MAPK Inhibitory Potential

Paul, Atish Tulshiram (ACS, 2007-11)

The target for the anti-inflammatory natural products like amentoflavone (2), which act by interfering with the proinflammatory cytokine pathway (e.g., TNF-α, IL-1β, and NO synthase), is not yet well-defined. Data obtained ...
Nanotechnological interventions for treatment of trypanosomiasis in humans and animals

Paul, Atish Tulshiram (Springer, 2020-05)

Trypanosomiasis is a parasitic infection caused by Trypanosoma. It is one of the major causes of deaths in underprivileged, rural areas of Africa, America and Asia. Depending on the parasite species responsible for the ...
Metagenomic analysis for taxonomic and functional potential of Polyaromatic hydrocarbons (PAHs) and Polychlorinated biphenyl (PCB) degrading bacterial communities in steel industrial soil

Paul, Atish Tulshiram; Jha, Prabhat Nath (PLOS, 2022-04)

Iron and steel industries are the major contributors to persistent organic pollutants (POPs). The microbial community present at such sites has the potential to remediate these contaminants. The present study highlights ...
Design, synthesis, in silico molecular modelling studies and biological evaluation of novel indole-thiazolidinedione hybrid analogues as potential pancreatic lipase inhibitors

Paul, Atish Tulshiram (RSC, 2021)

Pancreatic lipase (PL) is a key enzyme responsible for the digestion of dietary triglycerides; hence its inhibition is considered as a promising target for the management and/or treatment of obesity. A new series of ...
Design, synthesis, biological evaluation, and molecular modeling studies of rhodanine derivatives as pancreatic lipase inhibitors

Paul, Atish Tulshiram (Wiley, 2019-08)

A series of rhodanine-3-acetic acid derivatives were synthesized via Knoevenagel condensation of rhodanine-3-acetic acid with various substituted aromatic aldehydes. The synthesized derivatives were screened in vitro for ...
Bis-indole alkaloids from Tabernaemontana divaricata as potent pancreatic lipase inhibitors: molecular modelling studies and experimental validation

Paul, Atish Tulshiram (Springer, 2017-03)

Obesity is the major leading cause of global mortality among metabolic disorders. Orlistat, a pancreatic lipase inhibitor, is the only approved drug of choice for the long term treatment of obesity. However, recent findings ...
Evaluation of Apoptosis and Autophagy Inducing Potential of Berberis aristata, Azadirachta indica, and Their Synergistic Combinations in Parental and Resistant Human Osteosarcoma Cells

Paul, Atish Tulshiram; Chowdhury, Rajdeep (Frontiers, 2017-12)

Cancer is a multifactorial disease and hence can be effectively overcome by a multi-constituently therapeutic strategy. Medicinal plant extracts represent a perfect example of such stratagem. However, minimal studies have ...
Fungal endophytes associated with Viola odorata Linn. as bioresource for pancreatic lipase inhibitors

Paul, Atish Tulshiram (Springer, 2017-08)

As per the recent statistical reports of World Health Organisation (WHO), 13% of total global population is obese. Orlistat remains to be the only drug approved for the long term treatment of obesity. Recent findings ...
Design, synthesis, biological evaluation and molecular modelling studies of indole glyoxylamides as a new class of potential pancreatic lipase inhibitors

Paul, Atish Tulshiram (Elsevier, 2019-04)

A series of eighteen indole glyoxylamide analogues were synthesized, characterized and evaluated for their pancreatic lipase inhibitory activity. Porcine pancreatic lipase (Type II) was used with 4-nitrophenyl butyrate (as ...
Design, synthesis, biological evaluation and molecular modelling studies of novel diaryl substituted pyrazolyl thiazolidinediones as potent pancreatic lipase inhibitors

Paul, Atish Tulshiram (Elsevier, 2017-08)

A series of novel diaryl substituted pyrazolyl 2,4-thiazolidinediones were synthesized via reaction of appropriate pyrazolecarboxaldehydes with 2,4-thiazolidinedione (TZD) and nitrobenzyl substituted 2,4-thiazolidinedione. ...
Synthesis, evaluation and molecular modelling studies of 2-(carbazol-3-yl)-2-oxoacetamide analogues as a new class of potential pancreatic lipase inhibitors

Kumar, Dalip; Paul, Atish Tulshiram (Elsevier, 2017-01)

A series of twenty four 2-(carbazol-3-yl)-2-oxoacetamide analogues were synthesized, characterized and evaluated for their pancreatic lipase (PL) inhibitory activity. Porcine PL was used against 4-nitrophenyl butyrate ...
Liquid chromatography–mass spectrometry-based quantification of steroidal glycoalkaloids from Solanum xanthocarpum and effect of different extraction methods on their content

Paul, Atish Tulshiram (Elsevier, 2008-10)

A new liquid chromatography–mass spectrometry (LC–MS)-based method coupled with pressurized liquid extraction (PLE) as an efficient sample preparation technique has been developed for the quantification and fingerprint ...
Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus

Paul, Atish Tulshiram (Elsevier, 2010-08)

A series of Sarsapogenin and Diosgenin derived steroidal constituents (1-12), isolated from Solanum xanthocarpum and Asparagus racemosus were screened for their ability to induce cell death and apoptosis of colon carcinoma ...

Now showing items 381-400 of 772

Search DSpace

Advanced Search

Browse

All of DSpace
This Collection
- By Issue Date
- Authors
- Titles
- Subjects

Recently added

Department of Pharmacy: Recent submissions

Search DSpace

Browse

All of DSpace

This Collection

My Account