Kidney diseases can be defined as abnormalities in the kidney structure, and loss of kidney function, which can progress to kidney failure and uremic death [1]. The pathogenesis of kidney diseases can arise from environmental ...

Vascular endothelial dysfunction (VED) significantly results in catastrophic cardiovascular diseases with multiple aetiologies. Variations in vasoactive peptides, including angiotensin II and endothelin 1, and metabolic ...

Fibromyalgia syndrome (FMS) is a devastating musculoskeletal disorder with characteristic symptoms of fatigue, chronic pain, headache, anxiety, morning stiffness, and memory loss that ultimately affects the quality of life. ...

Persistent hyperglycemia in type 1 diabetes triggers numerous signaling pathways, which may prove deleterious to the endothelium. As hyperglycemia damages the endothelial layer via multiple signaling pathways, including ...

Kidney disease is the 6th fastest-growing cause of death and a serious global health concern that urges effective therapeutic options. The inflammatory response is an initial reaction from immune and parenchymal cells in ...

Diabetes mellitus is a chronic metabolic disease. In the past few decades, it has become a serious health problem in both developed and developing countries. The rising burden of diabetes has affected the economy and health ...

Persistent hyperglycaemia increases SET7/9 expression and endoplasmic reticulum (ER) stress which causes inflammation, apoptosis, and fibrosis in renal tubular epithelial cells leading to diabetic kidney disease (DKD)

Poly(ADP-ribosyl)ation is one of the most pertinent post translational modifications involved in regulation of chromatin structure, cell cycle progression, tissue development and differentiation and other vital biological ...

This study explored the role of the depressor arm of renin-angiotensin system (RAS) on ischemic renal injury (IRI)-associated cardio-hepatic sequalae under non-diabetic (ND) and diabetes mellitus (DM) conditions. Firstly, ...

Diabetic kidney disease (DKD) is a major diabetic complication and global health concern, occurring in nearly 30 % to 40 % of people with diabetes. Importantly, several therapeutic strategies are being used against DKD; ...