Department of Pharmacy: Recent submissions

Now showing items 461-480 of 772

FoxO1 Inhibitors: The Future Medicine for Metabolic Disorders?

Gaikwad, Anil Bhanudas (Bentham Science, 2016)

FoxO1, one of the most widely expressed sub-families of the winged helix forkhead factors, is biologically ‘omni-functional’ owing to its far-flung roles in metabolism, cell cycle, tissue differentiation and development ...
H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats

Gaikwad, Anil Bhanudas (Elsevier, 2016-12)

Monocyte chemoattractant protein (MCP-1) and transforming growth factor-β (TGF-β1)-markers of inflammation and fibrosis, are central to type 2 diabetic nephropathy (T2DN) progression. The epigenetic basis of their expression ...
Evidence for Use or Disuse of Renin–Angiotensin System Modulators in Patients Having COVID-19 With an Underlying Cardiorenal Disorder

Gaikwad, Anil Bhanudas (Sage, 2020-04)

Coronavirus disease 19 (COVID-19) originated in Wuhan, China, in December 2019 has been declared pandemic by World Health Organization due to an exponential rise in the number of infected and deceased persons across the ...
Esculetin reverses histone H2A/H2B ubiquitination, H3 dimethylation, acetylation and phosphorylation in preventing type 2 diabetic cardiomyopathy

Gaikwad, Anil Bhanudas (Elsevier, 2015-08)

Post translational histone modifications (PTHMs) play a pivotal role in pathogenesis of diabetic complications. Esculetin is reported to prevent glomerulosclerosis by reversing PTHMs in diabetic rats, but until now its ...
Diabetes, diabetic complications, and flavonoids

Gaikwad, Anil Bhanudas (Elsevier, 2016)

Diabetes mellitus is among the most prevalent diseases with which a large population of world is suffering from. Incidence of diabetes is on rise all over the world. Hence management of diabetes and related complications ...
Hidden targets of ubiquitin proteasome system: To prevent diabetic nephropathy

Gaikwad, Anil Bhanudas (Elsevier, 2017-06)

Diabetic nephropathy (DN) is the major cause of end stage renal failure. Although, several therapeutic targets have emerged to prevent the progression of DN, the number of people with DN still continues to rise worldwide, ...
AT2 receptor agonist Compound 21: A silver lining for diabetic nephropathy

Gaikwad, Anil Bhanudas (Elsevier, 2017-11)

The currently available therapies for diabetic nephropathy, one of the leading causes of renal failure globally are based on inhibition of renin angiotensin system. However, recently, the focus has shifted towards activation ...
Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats

Gaikwad, Anil Bhanudas (Wiley, 2010-10)

Type 2 diabetes is associated with an increased risk for developing fatty liver disease, which results in an increased incidence of diabetic nephropathy. Hence, the present study was conceived to identify transcriptional ...
Compound 21 and Telmisartan combination mitigates type 2 diabetic nephropathy through amelioration of caspase mediated apoptosis

Gaikwad, Anil Bhanudas (Elsevier, 2017-06)

The current study aimed to understand the role of novel, highly selective, orally active, non-peptide Angiotensin II type 2 receptor (AT2R) agonist, Compound 21 and its potential additive effect with Telmisartan on apoptosis ...
Histone Acetylation Regulates Natriuretic Peptides and Neprilysin Gene Expressions in Diabetic Cardiomyopathy and Nephropathy

Gaikwad, Anil Bhanudas (Bentham Science, 2019)

Natriuretic peptide system (NPS) alterations are involved in pathogenesis of diabetic cardiomyopathy (DCM) and nephropathy (DN), however its epigenetic regulation is still unclear. Interestingly, histone acetylation ...
Esculetin: A phytochemical endeavor fortifying effect against non-communicable diseases

Gaikwad, Anil Bhanudas (Elsevier, 2016-12)

Esculetin, a naturally occurring 6,7-dihydroxy derivative of coumarin has shown its potential role in various non-communicable diseases (NCDs) including obesity, diabetes, cardiovascular, renal failure, cancer and neurological ...
Angiotensin II type 2 receptor and angiotensin-converting enzyme 2 mediate ischemic renal injury in diabetic and non-diabetic rats

Gaikwad, Anil Bhanudas (Elsevier, 2019-10)

Depressor arm of the renin-angiotensin system (RAS) exerts reno-protective effects in chronic kidney diseases like diabetic nephropathy. However, same is still elusive under AKI and hyperglycaemia comorbidity. Hence, the ...
Esculetin attenuates alterations in Ang II and acetylcholine mediated vascular reactivity associated with hyperinsulinemia and hyperglycemia

Gaikwad, Anil Bhanudas (Elsevier, 2015-05)

Esculetin (6, 7- dihydroxycoumarin) was found to be protective against hepatic and renal damage associated with Streptozotocin (STZ) induced type 1 diabetes, because of its radical scavenging property. However, there are ...
Differential regulation of angiotensin converting enzyme 2 and nuclear factor-κB by angiotensin II receptor subtypes in type 2 diabetic kidney

Gaikwad, Anil Bhanudas (Elsevier, 2015-11)

Angiotensin II (Ang II) acts through Angiotensin Converting Enzyme (ACE)/Ang II type 1 receptor (AT1R) axis to promote renal failure whereas the Ang II type 2 receptor (AT2R)/Angiotensin Converting Enzyme 2 (ACE2)/Ang1–7/Mas ...
E3 ubiquitin ligases as novel targets for inflammatory diseases

Gaikwad, Anil Bhanudas (Elsevier, 2016-04)

Ubiquitination is one of the post translational modifications which decide the fate of various proteins in the cells, by either directing them towards proteasomal degradation or participation in several cell signalling ...
Esculetin ameliorates hepatic fibrosis in high fat diet induced non-alcoholic fatty liver disease by regulation of FoxO1 mediated pathway

Gaikwad, Anil Bhanudas (Elsevier, 2017-08)

Non-alcoholic fatty liver disease (NAFLD), a chronic metabolic disorder is associated with oxidative stress, inflammation and fibrotic cascades. In this study, we aimed to examine the effects of Esculetin, a well-known ...
Concurrent neprilysin inhibition and renin-angiotensin system modulations prevented diabetic nephropathy

Gaikwad, Anil Bhanudas (Elsevier, 2019-03)

Renin-angiotensin system (RAS) and natriuretic peptides system (NPS) perturbations govern the development of diabetic nephropathy (DN). Hence, in search of a novel therapy against DN, present study targeted both, NPS and ...
Combination of aspirin with telmisartan suppresses the augmented TGFβ/smad signaling during the development of streptozotocin-induced type I diabetic nephropathy

Gaikwad, Anil Bhanudas (Elsevier, 2010-04)

Diabetic nephropathy (DN) is the most common indication for the development of end stage renal diseases. Inflammation is increasingly seen as the core process in the development of diabetes. Inflammatory markers e.g. NFκB ...
Histone H2AK119 and H2BK120 mono-ubiquitination modulate SET7/9 and SUV39H1 in type 1 diabetes-induced renal fibrosis

Gaikwad, Anil Bhanudas (Portland Press, 2016-10)

Hyperglycaemia-induced expression of extracellular matrix (ECM) components plays a major role in the development of diabetic nephropathy (DN). The epigenetic mechanisms that modulate ECM gene expression in DN remain unclear. ...
Neprilysin inhibitors: A new hope to halt the diabetic cardiovascular and renal complications?

Gaikwad, Anil Bhanudas (Elsevier, 2017-06)

Diabetes is an enormous and ever-growing calamity and a global public health threat of the 21st century. Besides insulin and oral hypoglycaemic drugs, blockage of the renin-angiotensin system (RAS) denotes a key pharmacotherapy ...

Now showing items 461-480 of 772

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