Department of Pharmacy: Recent submissions

Now showing items 541-560 of 772

QbD-driven development and validation of HPLC method for determination of Bisphenol A and Bis-sulphone in environmental samples

Taliyan, Rajeev (Taylor & Francis, 2019-06)

A large number of hazardous chemicals have entered the environment due to the rapid growth of urbanisation and industrial development and are exerting harmful effects on wildlife as well as on human health. Plastic materials ...
Biological toxicity of nanoparticles

Taliyan, Rajeev (Elsevier, 2022)

Multiple biological barriers and discrepancy in releasing the optimal dosage range pose a great challenge in the current therapeutic management for majority of diseases. Nanoparticle drug delivery system (5–250 nm) possesses ...
Orchestration of the circadian clock and its association with Alzheimer's disease: Role of endocannabinoid signaling

Taliyan, Rajeev (Elsevier, 2022-01)

Circadian rhythms are 24-hour natural rhythms regulated by the suprachiasmatic nucleus, also known as the "master clock". The retino-hypothalamic tract entrains suprachiasmatic nucleus with photic information to synchronise ...
A novel UPLC–MS/MS method for simultaneous quantification of trigonelline, 4-hydroxyisoleucine, and diosgenin from Trigonella foenum-graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats

Taliyan, Rajeev (Wiley, 2021-11)

Trigonelline (TR), 4-hydroxyisoleucine (4-HI), and diosgenin (DG) are the main bioactives of the purified standardized extract of the popular plant Trigonella foenum-graecum L. (TFG), and it has been proven effective for ...
Pre-clinical pharmacokinetic and pharmacodynamic modelling study of 4-hydroxyisoleucine using validated ultra-performance liquid chromatography-tandem mass spectrometry

Taliyan, Rajeev (RSC, 2020)

A reliable and sensitive ultra-performance liquid chromatography-tandem mass spectrometry-based method has been developed for the estimation of 4-hydroxyisoleucine (4-HI), a potent insulinotropic and hypolipidemic agent. ...
Development and validation of RP-HPLC method for quantification of repaglinide in mPEG-PCL polymeric nanoparticles: QbD-driven optimization, force degradation study, and assessment of in vitro release mathematic modeling

Taliyan, Rajeev (Elsevier, 2021-09)

Repaglinide (REP) an insulinotropic agent used in the treatment of type-2 diabetes. It belongs to meglitinides, which act by blocking the ATP sensitive potassium channels and stimulates the insulin release. REP is the first ...
Evaluation of thyroid hormone induced pharmacological preconditioning on cardiomyocyte protection against ischemic-reperfusion injury

Taliyan, Rajeev (Mednow Pubications, 2012)

Ischemic preconditioning (IPC) has been demonstrated to make myocardium transiently more resistant to deleterious effect of prolonged ischemia. The opening of the mitochondrial permeability transition pore (mPTP) at the ...
Neuroprotective efficacy of co-encapsulated rosiglitazone and vorinostat nanoparticle on streptozotocin induced mice model of Alzheimer disease

Taliyan, Rajeev; Chitkara, Deepak (ACS, 2021-04)

Anomalies in brain insulin signaling have been demonstrated to be involved in the pathology of Alzheimer disease (AD). In this context, the neuroprotective efficacy of an insulin sensitizer, rosiglitazone, has been confirmed ...
Neuroprotective Effects of Trehalose and Sodium Butyrate on Preformed Fibrillar Form of α-Synuclein-Induced Rat Model of Parkinson’s Disease

Taliyan, Rajeev (ACS, 2021-07)

Therapeutic options for Parkinson’s disease (PD) are limited to a symptomatic approach, making it a global threat. Targeting aggregated alpha-synuclein (α-syn) clearance is a gold standard for ameliorating PD pathology, ...
Nanocarrier mediated drug delivery as an impeccable therapeutic approach against Alzheimer’s disease

Taliyan, Rajeev; Singhvi, Gautam (Elsevier, 2022-03)

For the past several years, dementia, is one of the predominantly observed groups of symptoms in a geriatric population. Alzheimer’s disease (AD) is a progressive memory related neurodegenerative disease, for which the ...
Fibroblast growth factor 21 and autophagy: A complex interplay in Parkinson disease

Taliyan, Rajeev (Elsevier, 2020-07)

Parkinson disease (PD) is a progressive and an age-dependent neurodegenerative disorder that predominantly affects the dopaminergic (DA) neuronal system in the substantia nigra (SN) region of the brain causing its deterioration ...
Protective effect of remote limb post conditioning via upregulation of heme oxygenase-1/BDNF pathway in rat model of cerebral ischemic reperfusion injury

Taliyan, Rajeev (Elsevier, 2017-08)

Remote ischemic post conditioning (RIPOC) has shown to be neuroprotective against cerebral ischemic reperfusion (I/R) injury. However, the RIPOC protection against I/R injury induced cognitive abnormalities still remains ...
High fat diet feeding induced insulin resistance exacerbates 6-OHDA mediated neurotoxicity and behavioral abnormalities in rats

Taliyan, Rajeev (Elsevier, 2018-10)

Some of the clinical reports suggest that insulin resistance could be a risk factor for Parkinson’s disease (PD) development, however experimental data is scarce. Our previous work has suggested that insulin resistance ...
Therapeutic Approaches to Alzheimer’s Type of Dementia: A Focus on FGF21 Mediated Neuroprotection

Taliyan, Rajeev (Bentham Science, 2019)

Neurodegenerative disorders are the most devastating disorder of the nervous system. The pathological basis of neurodegeneration is linked with dysfunctional protein trafficking, mitochondrial stress, environmental factors ...
Effect of dipyrone and thalidomide alone and in combination on STZ-induced diabetic neuropathic pain

Taliyan, Rajeev (Springer, 2012-01)

Diabetic neuropathy is recognized as one of the most common complications of chronic diabetes, but its pathophysiological mechanism is complex and yet to be completely explored. Monotherapy with conventional analgesics ...
Exploring the Neuroprotective Potential of Rosiglitazone Embedded Nanocarrier System on Streptozotocin Induced Mice Model of Alzheimer’s Disease

Taliyan, Rajeev; Chitkara, Deepak; Marathe, Sandhya (Springer, 2020-07)

Alzheimer’s disease (AD) is a neurodegenerative disorder imposing great threat to an individual’s cognitive capability. Mounting evidence suggests that type 2 diabetes mellitus (T2DM) and AD is closely associated with ...
Possible involvement of α1-adrenergic receptor and KATP channels in cardioprotective effect of remote aortic preconditioning in isolated rat heart

Taliyan, Rajeev (Elsevier, 2010-09)

Remote preconditioning is a phenomenon in which brief episodes of ischemia and reperfusion to remote organs protect the target organ against sustained ischemia/reperfusion (I/R)-induced injury. Protective effects of remote ...
Recent advances in nanocarriers for nutrient delivery

Taliyan, Rajeev; Singhvi, Gautam (Springer, 2022)

For the past few years, there has been a surge in the use of nutraceuticals. The global nutraceuticals market in 2020 was USD 417.66 billion, and the market value is expected to increase by 8.9% compound annual growth rate ...
Delayed neuroprotection against cerebral ischemia reperfusion injury: putative role of BDNF and GSK-3β

Taliyan, Rajeev (Taylor & Francis, 2015-11)

Numerous studies have demonstrated the possible neuroprotective role of lithium treatment against neurological disorders. However, the role of lithium in delayed phase of neuronal death against focal ischemia has not been ...
Repurposing methylene blue in the management of COVID-19: Mechanistic aspects and clinical investigations

Taliyan, Rajeev (Elsevier, 2021-10)

The severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is the most recent coronaviruses, which has infected humans, and caused the disease COVID-19. The World Health Organization has declared COVID-19 as a pandemic ...

Now showing items 541-560 of 772

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