Department of Pharmacy: Recent submissions

Now showing items 61-80 of 960

Drug repurposing: an effective tool in modern drug discovery

Murugesan, Sankaranarayanan (Springer, 2023-02)

Drug repurposing is using an existing drug for a new treatment that was not indicated before. It has received immense attention during the COVID-19 pandemic emergency. Drug repurposing has become the need of time to fasten ...
Advances in the synthesis of diarylpyrimidine as potent non-nucleoside reverse transcriptase inhibitors: biological activities, molecular docking studies and structure-activity relationship: a critical review

Murugesan, Sankaranarayanan (Bentham Science, 2023-04)

Acquired immunodeficiency syndrome (AIDS) is an ailment that is caused primarily by the Human immunodeficiency virus (HIV), which is the main agent responsible for this deadly disease. Of all the different inhibitors ...
Design, synthesis, and biological evaluation of novel quinazolin-4(3h)-one-based histone deacetylase 6 (hdac6) inhibitors for anticancer activity

Murugesan, Sankaranarayanan (MDPI, 2023-07)

A series of novel quinazoline-4-(3H)-one derivatives were designed and synthesized as histone deacetylase 6 (HDAC6) inhibitors based on novel quinazoline-4-(3H)-one as the cap group and benzhydroxamic acid as the linker ...
Design, synthesis, graph theoretical analysis and molecular modelling studies of novel substituted quinoline analogues as promising anti-breast cancer agents

Murugesan, Sankaranarayanan (Springer, 2022-08)

The most promising class of heterocyclic compounds in medicinal chemistry are those with the quinolin-2-one nucleus. It is a versatile heterocyclic molecule that has been put together with numerous pharmaceutical substances ...
Design, synthesis and biological evaluation of novel oxindole analogs as antitubercular agents

Murugesan, Sankaranarayanan (Taylor & Francis, 2023-08)

We synthesized the derivatives, confirmed their structures by 1H/13C NMR and mass spectrometry, and evaluated them for antitubercular activity against Mycobacterium tuberculosis H37Rv strain using the microplate alamarBlue™ ...
Network analysis and in silico molecular modeling of bioactive compounds from sida cordifolia against NMDA receptor

Murugesan, Sankaranarayanan (World Scientific, 2023)

Epilepsy, one of the most common neurological disorders, is characterized by continuing predisposition of epileptic seizures. Abnormal discharges of seizures burst the electrical functions in the brain leading to unprompted ...
An in silico investigation to identify promising inhibitors for sars-cov-2 mpro target

Murugesan, Sankaranarayanan (Bentham Science, 2023-11)

A limited number of small molecules against SARS-CoV-2 has been discovered since the epidemic commenced in November 2019. The conventional medicinal chemistry approach demands more than a decade of the year of laborious ...
Effects of acute and repeated dose toxicity profiling of chelidonic acid in rats: in silico and in vivo evidence

Murugesan, Sankaranarayanan (Wiley, 2023-11)

Chelidonic acid is a phytoconstituent found in rhizomes of the perennial plant celandine. The current study aims to evaluate the acute and repeated dose oral toxicity study of chelidonic acid as per the OECD guidelines 425 ...
Pharmacophore modelling-based drug repurposing approaches for monkeypox therapeutics

Murugesan, Sankaranarayanan (Taylor & Francis, 2022-09)

Monkeypox is a zoonotic viral disease that mainly affects tropical rainforest regions of central and west Africa, with sporadic exportations to other places. Since there is no cure, treating monkeypox with an antiviral ...
Design, synthesis, and anti-mycobacterial evaluation of 1,8-naphthyridine-3-carbonitrile analogues

Murugesan, Sankaranarayanan (RSC, 2024-07)

Twenty-eight compounds, viz., 1,8-naphthyridine-3-carbonitrile (ANC and ANA) derivatives, were designed and synthesized through a molecular hybridization approach. The structures of these compounds were analyzed and confirmed ...
Development and biological evaluation of novel spiro 4-chromanones as potent quorum sensing inhibitors

Murugesan, Sankaranarayanan (Wiley, 2024-08)

Infectious diseases are an integral part of human life and have the potential to cause significant damage to life. Currently, antimicrobial agents are no longer effective, as most human pathogenic microbes have developed ...
Polyamine metabolism for drug intervention in trypanosomatids

Murugesan, Sankaranarayanan (MDPI, 2024)

Neglected tropical diseases transmitted by trypanosomatids include three major human scourges that globally affect the world’s poorest people: African trypanosomiasis or sleeping sickness, American trypanosomiasis or Chagas ...
Synthesis, anti-acetylcholinesterase evaluation, molecular docking and molecular dynamics simulation of novel psoralen derivatives

Murugesan, Sankaranarayanan (Bentham Science, 2024-02)

Seven new psoralen derivatives were synthesised by carbodiimide coupling to active carboxylic acid to amide formation in mild reaction conditions. Methods: The psoralen derivatives were produced through the condensation ...
Potential inhibitors from natural compounds against sars-cov-2 main protease: a systematic molecular modelling approach

Murugesan, Sankaranarayanan (Wiley, 2024-02)

The COVID-19 outbreak poses a significant threat to the world‘s human population in 2020. Finding new drugs rapidly during this pandemic is quite challenging. Thus, in silico drug screening experiments may provide effective ...
Design, synthesis, and biological evaluation of novel quinoxaline aryl ethers as anticancer agents

Murugesan, Sankaranarayanan (Wiley, 2024-03)

We designed and synthesized thirty novel quinoxaline aryl ethers as anticancer agents, and the structures of final compounds were confirmed with various analytical techniques like Mass, 1H NMR, 13C NMR, FTIR, and elemental ...
Molecular docking and dynamics identify potential drugs to be repurposed as sars-cov-2 inhibitors

Murugesan, Sankaranarayanan (World Scientific, 2024)

The novel coronavirus disease 19 (COVID-19) has resulted in an estimated 20 million excess deaths and the recent resurgence of COVID-19 in China is predicted to result in up to 1 million deaths over the next few months. ...
In silico screening of some active phytochemicals to identify promising inhibitors against sars-cov-2 targets

Murugesan, Sankaranarayanan (Bentham Science, 2024-05)

There are very few small-molecule drug candidates developed against SARS-CoV-2 that have been revealed since the epidemic began in November 2019. The typical medicinal chemistry discovery approach requires more than a ...
Synthesis, biological evaluation and molecular modeling studies of modulated benzyloxychalcones as potential acetylcholinesterase inhibitors

Murugesan, Sankaranarayanan (Taylor & Francis, 2023-06)

Acetylcholinesterase inhibitors (AChEIs) have become a significant target in the search for an efficient treatment of Alzheimer’s disease. Chalcone-based compounds display a strong potency to hinder AChE. So, this study ...
Design, synthesis and biological evaluation of novel pyrido-[2,3-d]-pyrimidin-2-amine analogues as antimycobacterial agents

Murugesan, Sankaranarayanan (Elsevier, 2024-05)

Thirty-eight novel Pyrido-[2,3-d]-pyrimidin-2-amine derivatives (P1-P38) were designed, synthesized, and their structures confirmed using analytical techniques viz., 1H NMR, 13C NMR, and mass spectrometry. Using the ...
Computational screening of some phytochemicals to identify best modulators for ligand binding domain of estrogen receptor alpha

Murugesan, Sankaranarayanan (Bentham Science, 2024-06)

The peculiar aim of this study is to discover and identify the most effective and potential inhibitors against the most influential target ERα receptor by in silico studies of 45 phytochemicals from six diverse ayurvedic ...

Now showing items 61-80 of 960

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