Department of Pharmacy: Recent submissions

Now showing items 601-620 of 772

Design, synthesis and structure–activity relationship studies of novel spirochromanone hydrochloride analogs as anticancer agents

Murugesan, Sankaranarayanan (Future Science Group, 2022-01)

Literature reports suggest spirochromanone derivatives exhibit anticancer activity. Methodology: The authors designed and synthesized 18 spirochromanone derivatives (Csp 1–18). The compounds were characterized and evaluated ...
In-vivo and in-silico toxicity studies of daidzein: an isoflavone from soy

Murugesan, Sankaranarayanan (Taylor & Francis, 2020-10)

Daidzein is a naturally occurring compound belonging to the class isoflavones and found in soya beans and other legumes. Acute oral toxicity was performed as per OECD guideline (TG 423) with slight modifications. A repeated ...
One-Pot Synthesis of Novel Hydrazono-1,3-Thıazolıdın-4-One Derivatives as Anti-HIV and Anti-Tubercular Agents: Synthesıs, Bıologıcal Evaluatıon, Molecular Modelling and Admet Studıes

Murugesan, Sankaranarayanan (Bentham Science, 2022)

The necessity for newer anti-HIV and anti-tubercular medications has arisen as a result of the prevalence of opportunistic infections caused by HIV (human immunodeficiency virus). Objective: A series of ten new hydrazono ...
Liposomes: An emerging carrier for targeting Alzheimer's and Parkinson's diseases

Murugesan, Sankaranarayanan (Elsevier, 2022-06)

The function of the brain can be affected by various factors that include infection, tumor, and stroke. The major disorders reported with altered brain function are Alzheimer's disease (AD), Parkinson's disease (PD), ...
Design, synthesis and evaluation of novel phenanthridine triazole analogs as potential antileishmanial agents

Murugesan, Sankaranarayanan (Future Science Group, 2022-06)

To synthesize and screen phenanthridine and 1,2,3-triazole derivatives for antileishmanial activity. Methodology: Synthesized analogs were tested for antileishmanial activity against transgenic strain of Leishmania infantum ...
Targeting a conserved pocket (n-octyl-β-D–glucoside) on the dengue virus envelope protein by small bioactive molecule inhibitors

Murugesan, Sankaranarayanan (Taylor & Francis, 2020-12)

Dengue virus enters the cell by receptor-mediated endocytosis followed by a viral envelope (DENVE) protein-mediated membrane fusion. A small detergent molecule n-octyl-β-D–glucoside (βOG) occupies the hydrophobic pocket ...
In silico and in vitro analysis of PPAR – α / γ dual agonists: Comparative evaluation of potential phytochemicals with anti-obesity drug orlistat

Murugesan, Sankaranarayanan (Elsevier, 2022-08)

Obesity is an abnormal fat accumulation disorder in the metabolic syndrome constellation, and a risk factor for diabetes, cardiovascular disorders, non-alcoholic fatty liver disease (NAFLD), and cancer. Nuclear receptors ...
Systematic Down-Selection of Repurposed Drug Candidates for COVID-19

Murugesan, Sankaranarayanan (MDPI, 2022)

SARS-CoV-2 is the cause of the COVID-19 pandemic which has claimed more than 6.5 million lives worldwide, devastating the economy and overwhelming healthcare systems globally. The development of new drug molecules and ...
Graph theoretical network analysis, in silico exploration, and validation of bioactive compounds from Cynodon dactylon as potential neuroprotective agents against α-synuclein

Murugesan, Sankaranarayanan (Tabriz University of Medical Sciences, 2022)

Parkinson's disease (PD) is a chronic, devastating neurodegenerative disorder marked by the death of dopaminergic neurons in the midbrain's substantia nigra pars compacta (Snpc). In alpha-synuclein (α-Syn) self-aggregation, ...
Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection

Murugesan, Sankaranarayanan (MDPI, 2022-10)

The repurposing of licenced drugs for use against COVID-19 is one of the most rapid ways to develop new and alternative therapeutic options to manage the ongoing pandemic. Given circa 7817 licenced compounds available from ...
CoviRx: A User-Friendly Interface for Systematic Down-Selection of Repurposed Drug Candidates for COVID-19

Murugesan, Sankaranarayanan (MDPI, 2022-11)

Although various vaccines are now commercially available, they have not been able to stop the spread of COVID-19 infection completely. An excellent strategy to get safe, effective, and affordable COVID-19 treatments quickly ...
Design and study of novel chromone and thiochromone derivatives as PfLDH inhibitors — computational approach

Murugesan, Sankaranarayanan (Springer, 2022-06)

Malaria is one of the most neglected diseases in the South African countries, which leads to many deaths each year and the currently available drugs in the market are day-by-day acquiring resistance towards the plasmodium ...
Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2-a]pyridine analogues

Murugesan, Sankaranarayanan (RSC, 2022)

Based on the molecular hybridization strategy, thirty-four imidazo[1,2-a]pyridine amides (IPAs) and imidazo[1,2-a]pyridine sulfonamides (IPSs) were designed and synthesized. The structures of the target compounds were ...
Molecular Docking and Dynamics Identifies Potential Repurposed Drug Candidates for COVID-19 Studies

Murugesan, Sankaranarayanan (2023-01)

The novel coronavirus disease 19 (COVID-19) has resulted in an estimated 20 million excess deaths and the recent resurgence of COVID-19 in China is predicted to result in up to 1 million deaths over the next few months. ...
Further Investigations of Nitroheterocyclic Compounds as Potential Antikinetoplastid Drug Candidates

Murugesan, Sankaranarayanan (MDPI, 2023-04)

Due to the lack of specific vaccines, management of the trypanosomatid-caused neglected tropical diseases (sleeping sickness, Chagas disease and leishmaniasis) relies exclusively on pharmacological treatments. Current drugs ...
Discovery of potent DNMT1 inhibitors against sickle cell disease using structural-based virtual screening, MM-GBSA and molecular dynamics simulation-based approaches

Murugesan, Sankaranarayanan (Taylor & Francis, 2023-04)

Sickle cell disease (SCD) is an autosomal recessive genetic disorder affecting millions of people worldwide. A reversible and selective DNMT1 inhibitor, GSK3482364, has been known to decrease the overall methylation activity ...
Discovery of Novel Coumarin-Schiff Base Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Computational Studies

Murugesan, Sankaranarayanan (MDPI, 2023-07)

To discover anti-acetylcholinesterase agents for the treatment of Alzheimer’s disease (AD), a series of novel Schiff base-coumarin hybrids was rationally designed, synthesized successfully, and structurally characterized ...
Pharmacoinformatics-Based Approach for Uncovering the Quorum-Quenching Activity of Phytocompounds against the Oral Pathogen, Streptococcus mutans

Murugesan, Sankaranarayanan (MDPI, 2023-07)

Streptococcus mutans, a gram-positive oral pathogen, is the primary causative agent of dental caries. Biofilm formation, a critical characteristic of S. mutans, is regulated by quorum sensing (QS). This study aimed to ...
In silico anti-viral assessment of phytoconstituents in a traditional (Siddha Medicine) polyherbal formulation – Targeting Mpro and pan-coronavirus post-fusion Spike protein

Murugesan, Sankaranarayanan; Deepa, P. R. (Elsevier, 2023-07)

Novel nature of the viral pathogen SARS-CoV-2 and the absence of standard drugs for treatment, have been a major challenge to combat this deadly infection. Natural products offer safe and effective remedy, for which ...
Molecular-level strategic goals and repressors in Leishmaniasis – Integrated data to accelerate target-based heterocyclic scaffolds

Murugesan, Sankaranarayanan (Elsevier, 2023-09)

Leishmaniasis is a complex of neglected tropical diseases caused by various species of leishmanial parasites that primarily affect the world's poorest people. A limited number of standard medications are available for this ...

Now showing items 601-620 of 772

Search DSpace

Advanced Search

Browse

All of DSpace
This Collection
- By Issue Date
- Authors
- Titles
- Subjects

Recently added

Department of Pharmacy: Recent submissions

Search DSpace

Browse

All of DSpace

This Collection

My Account