dc.contributor.author |
Jha, Prabhat N. |
|
dc.contributor.author |
Kumar, Dalip |
|
dc.date.accessioned |
2021-09-17T04:38:59Z |
|
dc.date.available |
2021-09-17T04:38:59Z |
|
dc.date.issued |
2018 |
|
dc.identifier.govdoc |
https://www.sciencedirect.com/science/article/pii/S0960894X18302221?via%3Dihub |
|
dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2043 |
|
dc.description.abstract |
A series of sixteen β-carbolines, bearing chalcone moiety at C-1 position, were prepared from easily accessible 1-acetyl-β-carboline and various aldehydes under basic conditions followed by N2-alkylation using different alkyl bromides. The prepared compounds were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. N2-Alkylated-β-carboline chalcones 13a-i represented the interesting anticancer activities compared to N2-unsubstituted β-carboline chalcones 12a-g. Off the prepared β-carbolines, 13g exhibited broad spectrum of activity with IC50 values lower than 22.5 µM against all the tested cancer cell lines. Further, the N2-alkylated-β-carboline chalcone 13g markedly induced cell death in MDA-MB-231 cells by AO/EB staining assay. The most cytotoxic compound 13g possessed a relatively high drug score of 0.48. Additionally, the prepared β-carboline chalcones displayed moderate antibacterial activities against tested bacterial strains. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Elsiever |
en_US |
dc.subject |
Biology |
en_US |
dc.subject |
β-Carboline chalcones |
en_US |
dc.subject |
β-Carbolinium chalcone bromides |
en_US |
dc.subject |
Anticancer activity |
en_US |
dc.subject |
Apoptosis |
en_US |
dc.subject |
Antibacterial activity |
en_US |
dc.title |
Synthesis and investigations into the anticancer and antibacterial activity studies of β-carboline chalcones and their bromide salts |
en_US |
dc.type |
Article |
en_US |