Abstract:
The interaction of the antibiotic drugs tetracycline and oxytetracycline with purines, pyrimidines and amino acids were studied spectrophotometrically in water, ethylene glycol and propylene glycol. In each case a new absorption band was located and denoted as a charge-transfer band. The formation constants for the charge-transfer complexes were determined using Benesi–Hildebrand's method followed by an iterative procedure. Different linear plots for hv against the highest filled π-molecular orbital of the donors (purines, pyrimidines and amino acids) were obtained indicating different stabilization energies for each system.
