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Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells

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dc.contributor.advisor
dc.contributor.advisor
dc.contributor.author Chowdhury, Rajdeep
dc.contributor.author Chowdhury, Shibasish
dc.contributor.author
dc.contributor.author Mukherjee, Sudeshna
dc.date.accessioned 2021-09-27T07:47:10Z
dc.date.available 2021-09-27T07:47:10Z
dc.date.issued 2021-01
dc.identifier.uri https://cancerci.biomedcentral.com/articles/10.1186/s12935-020-01720-y
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2141
dc.description.abstract Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We therefore planned to understand the molecular cause for its poor prognosis and design an appropriate therapeutic strategy to combat the disease. en_US
dc.language.iso en en_US
dc.publisher Springer Nature en_US
dc.subject Biology en_US
dc.subject Verteporfin en_US
dc.subject Autophagy en_US
dc.subject Osteosarcoma cells en_US
dc.title Verteporfin disrupts multiple steps of autophagy and regulates p53 to sensitize osteosarcoma cells en_US
dc.type Article en_US


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