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Engineering a light-driven cyanine based molecular rotor to enhance the sensitivity towards a viscous medium

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dc.contributor.author Chowdhury, Rajdeep
dc.contributor.author Laskar, Inamur Rahaman
dc.contributor.author Majumder, Syamantak
dc.contributor.author Mukherjee, Sudeshna
dc.date.accessioned 2021-09-27T07:47:27Z
dc.date.available 2021-09-27T07:47:27Z
dc.date.issued 2021
dc.identifier.uri https://pubs.rsc.org/en/content/articlelanding/2021/ma/d1ma00277e
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2143
dc.description.abstract This article describes the enhanced sensitivity to a viscous medium by a molecular rotor based fluorophore (RBF), TPSI I. The TPSI I molecule is designed in such a way that it consists of a rotor and a fluorophore with a π-rich bridge between them. TPSI I is a light-responsive material in solution as well as in the solid state. The structural design of the molecule allows flexible rotation and photo-induced cis–trans isomerization both in the solid state as well as in solution. These combined attributes of TPSI I are responsible for the ultrasensitive viscosity response of the new material, which was verified through the Förster–Hoffmann equation. According to this equation, the derived ‘x’ value is 1.02 (x is related to the sensitivity) which is the highest among the contemporary reports for RBFs. The facts were evidenced both by experimental as well as theoretical data. The ultrasensitivity towards viscosity was further analyzed in in vitro studies by detecting the subtle changes in the alteration of intracellular viscosity in normal and cancerous cells. An alteration of intracellular viscosity in cells treated with viscosity modulators was also confirmed using a previously well-established viscosity measurement technique, dynamic measurement through the piezoelectric patch. Our research offers a detailed mechanism to improve viscosity sensors and an efficient probe for detecting minute changes in intracellular viscosity. en_US
dc.language.iso en en_US
dc.publisher RSC en_US
dc.subject Biology en_US
dc.subject Cyanine en_US
dc.subject Intracellular viscosity en_US
dc.subject Chemistry en_US
dc.title Engineering a light-driven cyanine based molecular rotor to enhance the sensitivity towards a viscous medium en_US
dc.type Article en_US


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