| dc.contributor.author |
Majumder, Syamantak |
|
| dc.date.accessioned |
2021-10-02T17:48:19Z |
|
| dc.date.available |
2021-10-02T17:48:19Z |
|
| dc.date.issued |
2014-01 |
|
| dc.identifier.uri |
https://www.sciencedirect.com/science/article/pii/S0041010113004108?via%3Dihub |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2424 |
|
| dc.description.abstract |
Present report shows for the first time on the induction of in vitro angiogenesis by a 3.9 kDa novel peptide (RVVAP) purified from Russell's viper venom. Secondary structure of RVVAP is made up of 36.8% α-helix, 33.3% β pleated sheets and 29.9% turns. Optimum angiogenesis and significant elevation in endothelial migration were observed at 50 ng/ml of RVVAP treatment; above this concentration, progressive decrease in wound healing was noted. RVVAP (1.0 μg/ml) was non-cytotoxic to U87-MG, HeLa and HT-29 cells; however, increasing the RVVAP concentration above 500 ng/ml resulted in induction of chromosomal aberrations and delay in cell cycle kinetics of Chinese hamster ovary cells. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Elsiever |
en_US |
| dc.subject |
Biology |
en_US |
| dc.subject |
Angiogenesis |
en_US |
| dc.subject |
Chromosomal aberration |
en_US |
| dc.subject |
Cytotoxicity |
en_US |
| dc.subject |
Russell's viper |
en_US |
| dc.subject |
Wound healing |
en_US |
| dc.title |
Characterization of a pro-angiogenic, novel peptide from Russell's viper (Daboia russelii russelii) venom |
en_US |
| dc.type |
Article |
en_US |