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A density functional reactivity theory (DFRT) based approach to understand the interaction of cisplatin analogues with protecting agents

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dc.contributor.author Roy, Ram Kinkar
dc.date.accessioned 2021-10-12T11:32:59Z
dc.date.available 2021-10-12T11:32:59Z
dc.date.issued 2014-09-03
dc.identifier.uri https://link.springer.com/article/10.1007%2Fs10822-014-9790-7
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2728
dc.description.abstract In the present study some new insights are put into one of the major concern of cisplatin therapy and that is on the reduction of various cytotoxic and nephrotoxic side-effects of cisplatin analogues in cancer treatment. A better understanding of the interaction between different cisplatin analogues with various protecting agents can be achieved from the descriptors generated by density functional reactivity theory based comprehensive decomposition analysis of stabilization energy (Bagaria et al. in Phys Chem Chem Phys 11:8306–8315, 2009) scheme. Taking into account of three types of interactions i.e., of (1) Cisplatin analogues with DNA bases and base pairs (2) Cisplatin analogues with protecting agents and (3) Protecting agents with DNA bases, it is possible to develop a strategy (albeit qualitative) that suggests the best possible combinations of these drugs with protecting agents which can cause reduction in the toxic side-effects of cisplatin therapy. The sample set comprises of 96 pairs of cisplatin analogues and rescue agents and the generated data confirms the predictive power of the adopted strategy. en_US
dc.language.iso en en_US
dc.publisher Springer en_US
dc.subject Chemistry en_US
dc.subject Density functional reactivity theory (DFRT) en_US
dc.title A density functional reactivity theory (DFRT) based approach to understand the interaction of cisplatin analogues with protecting agents en_US
dc.type Article en_US


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