dc.contributor.author |
Sah, Ajay Kumar |
|
dc.date.accessioned |
2021-10-14T13:07:11Z |
|
dc.date.available |
2021-10-14T13:07:11Z |
|
dc.date.issued |
2020-02-17 |
|
dc.identifier.uri |
https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/slct.201904655 |
|
dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2774 |
|
dc.description.abstract |
A series of d-glucose derived N-glycopeptides containing mefenamic acid have been synthesised and in vitro evaluation of all these molecules have been performed as COX-2 (human) enzyme inhibitor using Enzymes Immuno Assay kit. These studies were further supported by docking experiments on human COX-2 enzyme (PDB ID: 5IKR). All the compounds exhibited a fair amount of COX-2 enzyme inhibition during both the modes of study and tryptophan derivative showed the best activity. Acute toxicity (LD50) in rat has also been evaluated using General Unrestricted Structure-Activity Relationships (GUSAR) software, where acute oral toxicity for most of the molecules was found to be less than the pure mefenamic acid. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.subject |
Chemistry |
en_US |
dc.subject |
Synthesis |
en_US |
dc.subject |
Mefenamic Acid Containing |
en_US |
dc.subject |
Enzyme Inhibitor |
en_US |
dc.title |
Synthesis of Mefenamic Acid Containing N-Glycoconjugates and Their Evaluation as Human COX-2 Enzyme Inhibitor |
en_US |
dc.type |
Article |
en_US |