| dc.contributor.author |
Kumar, Anil |
|
| dc.contributor.author |
Kumar, Dalip |
|
| dc.date.accessioned |
2021-10-14T13:11:22Z |
|
| dc.date.available |
2021-10-14T13:11:22Z |
|
| dc.date.issued |
2018-03-05 |
|
| dc.identifier.uri |
https://onlinelibrary.wiley.com/doi/10.1002/adsc.201701519 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2828 |
|
| dc.description.abstract |
A simple and efficient method for the synthesis of pyrazolo[5,1-a]isoquinoline derivatives has been developed using the nickel-catalyzed reaction of 1-aryl-2-(1H-pyrazol-1-yl)ethan-1-ones and 2-bromo aldehydes. The overall transformation involves tandem Knoevenagel condensation and intramolecular direct arylation via activation of the C5−H bond of the pyrazole ring. A series of 27 drug-like aroyl−substituted pyrazolo[5,1-a]isoquinolines has been synthesized in moderate to good yields. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Wiley |
en_US |
| dc.subject |
Chemistry |
en_US |
| dc.subject |
Nickel-Catalyzed |
en_US |
| dc.subject |
Synthesis of Pyrazolo |
en_US |
| dc.title |
Nickel-Catalyzed Tandem Knoevenagel Condensation and Intramolecular Direct Arylation: Synthesis of Pyrazolo[5,1-a]-isoquinoline Derivatives |
en_US |
| dc.type |
Article |
en_US |