Abstract:
A Cu-catalyzed tandem reaction of 2-(2-bromoaryl)imidazoles/2-(2-bromoaryl)benzmidazoles, alkynes, and sodium azide is developed for the synthesis of imidazo[1,2-c][1,2,3]triazolo[1,5-a]quinazolines in moderate to excellent yields. This one-pot protocol includes copper-catalyzed azide–alkyne cycloaddition (CuAAC), intramolecular cross-dehydrogenative coupling (CDC), and Ullmann-type C–N coupling.