dc.contributor.author |
Kumar, Anil |
|
dc.date.accessioned |
2021-10-14T13:13:17Z |
|
dc.date.available |
2021-10-14T13:13:17Z |
|
dc.date.issued |
2016-06-07 |
|
dc.identifier.uri |
https://onlinelibrary.wiley.com/doi/abs/10.1002/adsc.201600225 |
|
dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2845 |
|
dc.description.abstract |
An efficient protocol has been developed for the methylenation of imidazo[1,2-a]pyridines using dimethylacetamide (DMA) as methylene source in the presence of vanadyl acetylacetonate [VO(acac)2] as the catalyst and iodobenzene diacetate as the oxidant. The reaction involves coupling of sp3- and sp2-hybridized carbons and proceeds through the formation of an iminium ion. A wide variety of imidazo[1,2-a]pyridines were converted to bis(imidazo[1,2-a]pyridin-3-yl)methanes in good to excellent yields. A gram-scale reaction demonstrated the potential for the scale-up processes. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.subject |
Chemistry |
en_US |
dc.subject |
Vanadyl Acetylacetonate |
en_US |
dc.subject |
Catalyzed Methylenation |
en_US |
dc.subject |
Methylene |
en_US |
dc.title |
Vanadyl Acetylacetonate Catalyzed Methylenation of Imidazo[1,2-a]pyridines by Using Dimethylacetamide as a Methylene Source: Direct Access to Bis(imidazo[1,2-a]pyridin-3-yl)methanes |
en_US |
dc.type |
Article |
en_US |