dc.contributor.author |
Kumar, Anil |
|
dc.date.accessioned |
2021-10-14T13:13:29Z |
|
dc.date.available |
2021-10-14T13:13:29Z |
|
dc.date.issued |
2016 |
|
dc.identifier.uri |
https://pubs.rsc.org/en/content/articlelanding/2016/ob/c5ob02469b |
|
dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2848 |
|
dc.description.abstract |
A simple and efficient one-pot protocol has been demonstrated for the synthesis of imidazo[1,2-c]quinazoline derivatives through a copper catalyzed tandem reaction between substituted 2-(2-bromophenyl)-1H-imidazoles and formamide. The synthetic protocol involves initial Ullmann-type C–N coupling followed by intramolecular dehydrative cyclization. The method uses readily available 2-(2-bromophenyl)-1H-imidazoles as the starting materials to afford imidazo[1,2-c]quinazolines in moderate to good yields and provided 610 mg (71%) yield of 3a from a gram scale reaction. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
RSC |
en_US |
dc.subject |
Chemistry |
en_US |
dc.subject |
Copper-Catalyzed |
en_US |
dc.subject |
Dehydrative cyclization |
en_US |
dc.title |
Copper-catalyzed tandem Ullmann type C–N coupling and dehydrative cyclization: synthesis of imidazo[1,2-c]quinazolines |
en_US |
dc.type |
Article |
en_US |