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Synthesis of Aza-Fused Isoquinolines through Domino Cross-Aldol Condensation and Palladium-Catalyzed Intramolecular Direct Arylation

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dc.contributor.author Kumar, Anil
dc.contributor.author Kumar, Dalip
dc.date.accessioned 2021-10-17T13:57:45Z
dc.date.available 2021-10-17T13:57:45Z
dc.date.issued 2014
dc.identifier.uri https://agris.fao.org/agris-search/search.do?recordID=US201800063640
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2876
dc.description.abstract A straightforward method has been developed for the synthesis of aroyl-substituted imidazo-/benzimidazo-fused isoquinolines. The cascade reaction proceeds via a cross-aldol condensation of 2-(1H-imidazol-1-yl/benzimidazolyl-1-yl)-1-arylethanones and 2-bromobenzaldehyde followed by palladium-catalyzed intramolecular Câ H functionalization. This approach offers a simple and efficient alternative one-pot protocol for the assembly of imidazo/benzimidazo[2,1-a]isoquinolines in moderate to good yields. en_US
dc.language.iso en en_US
dc.publisher AGRIS en_US
dc.subject Chemistry en_US
dc.subject Isoquinolines en_US
dc.subject Palladium-catalyzed en_US
dc.title Synthesis of Aza-Fused Isoquinolines through Domino Cross-Aldol Condensation and Palladium-Catalyzed Intramolecular Direct Arylation en_US
dc.type Article en_US


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