| dc.contributor.author | Kumar, Anil | |
| dc.date.accessioned | 2021-10-17T13:58:46Z | |
| dc.date.available | 2021-10-17T13:58:46Z | |
| dc.date.issued | 2013 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960894X13011517?via%3Dihub | |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2890 | |
| dc.description.abstract | A series of twenty two novel 1-cyclopropyl-6-fluoro-4-oxo-7-(4-substituted piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid analogues have been synthesized, characterized (1H NMR, 13C NMR and LCMS) and evaluated for their inhibitory activity on the proliferation of human caucasian acute lymphoblastic leukemia cells (CCRF-CEM), breast adenocarcinoma cells (MDA-MB-468) and human colon carcinoma cells (HCT-116). Among all the synthesized ciprofloxacin analogues 3t at 50 μM showed comparable potency to doxorubicin (10 μM) in all three cell lines and 3j inhibited proliferation of MDA-MB-468 up to 35% selectively over other two cell lines. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsiever | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Synthesis | en_US |
| dc.subject | Ciprofloxacin analogues | en_US |
| dc.subject | Anti-proliferative | en_US |
| dc.title | Synthesis of novel ciprofloxacin analogues and evaluation of their anti-proliferative effect on human cancer cell lines | en_US |
| dc.type | Article | en_US |
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