Synthesis and Biological Evaluation of 2-Arylamino-5- (3′-Indolyl)-1,3,4-Oxadiazoles as Potent Cytotoxic Agents

dc.contributor.author	Kumar, Anil
dc.contributor.author	Kumar, Dalip
dc.date.accessioned	2021-10-17T13:59:06Z
dc.date.available	2021-10-17T13:59:06Z
dc.date.issued	2013
dc.identifier.uri	https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cmdc.201300221
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2895
dc.description.abstract	Coupling of two key scaffolds in medicinal chemistry, the indole and 1,3,4-oxadiazole ring systems, gave rise to 2-arylamino-5-(3′-indolyl)-1,3,4-oxadiazoles with IC50 values in the nanomolar range against a panel of tumor cell lines. Preliminary structure–activity relationship studies indicate potential for improved selectivity through further manipulation of the oxadiazole C-2 and C-5 positions.	en_US
dc.language.iso	en	en_US
dc.publisher	Wiley	en_US
dc.subject	Chemistry	en_US
dc.subject	Synthesis	en_US
dc.subject	Biological Evaluation	en_US
dc.subject	Potent Cytotoxic Agents	en_US
dc.title	Synthesis and Biological Evaluation of 2-Arylamino-5- (3′-Indolyl)-1,3,4-Oxadiazoles as Potent Cytotoxic Agents	en_US
dc.type	Article	en_US

Files in this item

Files	Size	Format	View
There are no files associated with this item.