A Greener Synthesis of 2-Aminochromenes in Ionic Liquid and Evaluation of Their Antiproliferative Activities

dc.contributor.author	Kumar, Anil
dc.date.accessioned	2021-10-27T04:09:21Z
dc.date.available	2021-10-27T04:09:21Z
dc.date.issued	2012
dc.identifier.uri	https://digitalcommons.chapman.edu/pharmacy_articles/87/
dc.identifier.uri	http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2915
dc.description.abstract	An improved simple and facile synthesis of chromene derivatives by employing three- component one-pot condensation reaction of β-naphthol, aromatic aldehydes, and malononitrile in ionic liquids is described. The ionic liquid can be reused and recycled. The chromene derivatives were evaluated for their anti-proliferative activity for human breast adenocarcinoma (MCF-7), ovarian adenocarcinoma (SK-OV-3), and acute lymphoblastic leukemia (CCRF-CEM) cell lines. Compounds 4b inhibited the cell proliferation of all three cancer cells by 60-80% at 50 μM. Among all compounds, compound 4b was the most potent against all three cancer cell lines whereas compound 4c, 4o and 4p exhibited more selectivity against CCRF-CEM.	en_US
dc.language.iso	en	en_US
dc.publisher	ISCB	en_US
dc.subject	Chemistry	en_US
dc.subject	One-pot	en_US
dc.subject	Multicomponent reaction	en_US
dc.subject	Ionic liquid	en_US
dc.title	A Greener Synthesis of 2-Aminochromenes in Ionic Liquid and Evaluation of Their Antiproliferative Activities	en_US
dc.type	Article	en_US

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