Abstract:
A novel porphyrin–cryptolepine conjugate 7 with a 1,2,3-triazole linker was synthesized by
the cycloaddition reaction of propargyl porphyrin 2 and azido cryptolepine 6 under click conditions.
The conjugate 7 exhibited enhanced photocytotoxicity against A549 cells with IC50 values of 2.5 μM
and 7.9 μM in the visible and UV light, respectively.