| dc.contributor.author | Kumar, Anil | |
| dc.date.accessioned | 2021-10-27T04:10:40Z | |
| dc.date.available | 2021-10-27T04:10:40Z | |
| dc.date.issued | 2011-03 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960894X11000709?via%3Dihub | |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2936 | |
| dc.description.abstract | A series of two classes of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates were synthesized using click chemistry approach. All compounds were evaluated for inhibition of Src kinase and human ovarian adenocarcinoma (SK-Ov-3), breast carcinoma (MDA-MB-361), and colon adenocarcinoma (HT-29). Hexyl triazolyl-substituted 3-phenylpyrazolopyrimidine exhibited inhibition of Src kinase with an IC50 value of 5.6 μM. 4-Methoxyphenyl triazolyl-substituted 3-phenylpyrazolopyrimidine inhibited the cell proliferation of HT-29 and SK-Ov-3 by 73% and 58%, respectively, at a concentration of 50 μM. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsiever | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Anticancer activity | en_US |
| dc.subject | Click reaction | en_US |
| dc.subject | Phenylpyrazolopyrimidine | en_US |
| dc.subject | Src kinase | en_US |
| dc.subject | 1,2,3-Triazole | en_US |
| dc.title | Synthesis of 3-phenylpyrazolopyrimidine-1,2,3-triazole conjugates and evaluation of their Src kinase inhibitory and anticancer activities | en_US |
| dc.type | Article | en_US |
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