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Click chemistry inspired structural modification of azole antifungal agents to synthesize novel ‘drug like’ molecules

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dc.contributor.author Khungar, Bharti
dc.contributor.author Kumar, Anil
dc.date.accessioned 2021-10-27T04:13:12Z
dc.date.available 2021-10-27T04:13:12Z
dc.date.issued 2012-12-12
dc.identifier.uri https://www.sciencedirect.com/science/article/pii/S0040403912017297?via%3Dihub
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/2980
dc.description.abstract A new class of ‘drug like’ 1,4-disubstituted-1,2,3-triazoles is synthesized using one-pot reaction of sodium azide, α-bromo ketones, and alkynes in PEG-400/water (1:1, v/v) under the click chemistry reaction condition followed by reduction of keto group and alkylation. The method is simple, efficient and gives good yield of novel 1,2,3-triazole derivatives. en_US
dc.language.iso en en_US
dc.publisher Elsiever en_US
dc.subject Chemistry en_US
dc.subject Click chemistry en_US
dc.subject 1,4-Disubstituted-1,2,3-triazoles en_US
dc.subject Drug like en_US
dc.title Click chemistry inspired structural modification of azole antifungal agents to synthesize novel ‘drug like’ molecules en_US
dc.type Article en_US


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