| dc.contributor.author |
Kumar, Dalip |
|
| dc.date.accessioned |
2021-10-27T04:18:46Z |
|
| dc.date.available |
2021-10-27T04:18:46Z |
|
| dc.date.issued |
2020-10 |
|
| dc.identifier.uri |
https://www.sciencedirect.com/science/article/pii/S0167488920301208?via%3Dihub |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3016 |
|
| dc.description.abstract |
Microtubules, the key components of the eukaryotic cytoskeleton and mitotic spindle, are one of the most sought-after targets for cancer chemotherapy, especially due to their indispensible role in mitosis. Cervical cancer is a prevalent malignancy among women of developing countries including India. In spite of the remarkable therapeutic advancement, the non-specificity of chemotherapeutic drugs adversely affect the patients' survival and well-being, thus, necessitating the quest for novel indole-based anti-microtubule agent against cervical cancer, with high degree of potency and selectivity. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
Elsiever |
en_US |
| dc.subject |
Chemistry |
en_US |
| dc.subject |
Microtubule |
en_US |
| dc.subject |
Cervical cancer |
en_US |
| dc.subject |
Bis (indolyl)-hydrazide-hydrazone |
en_US |
| dc.title |
NMK-BH2, a novel microtubule-depolymerising bis (indolyl)-hydrazide-hydrazone, induces apoptotic and autophagic cell death in cervical cancer cells by binding to tubulin at colchicine – site |
en_US |
| dc.type |
Article |
en_US |