dc.contributor.author | Kumar, Dalip | |
dc.date.accessioned | 2021-10-27T04:19:36Z | |
dc.date.available | 2021-10-27T04:19:36Z | |
dc.date.issued | 2016-03-29 | |
dc.identifier.uri | https://www.nature.com/articles/srep23401 | |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3029 | |
dc.description.abstract | A series of 5-(2′-indolyl)thiazoles were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of thioamides 3 with 3-tosyloxypentane-2,4-dione 4 led to in situ formation of 5-acetylthiazole 5 which upon treatment with arylhydrazines 6 in polyphosphoric acid resulted in the formation of 5-(2′-indolyl)thiazoles 2. Among the synthesized 5-(2′-indolyl)thiazoles, compounds 2d–f and 2h exhibited encouraging anticancer activity and also selectivity towards particular cell lines (IC50 = 10–30 μM). Further studies on the SAR of compound 2e may result in good anticancer activity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Nature | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Anticancer | en_US |
dc.subject | Synthesis | en_US |
dc.title | One-pot synthesis and in-vitro anticancer evaluation of 5-(2′-indolyl)thiazoles | en_US |
dc.type | Article | en_US |
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