dc.contributor.author |
Kumar, Dalip |
|
dc.date.accessioned |
2021-10-27T04:19:39Z |
|
dc.date.available |
2021-10-27T04:19:39Z |
|
dc.date.issued |
2016-12-09 |
|
dc.identifier.uri |
https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/slct.201601734 |
|
dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3030 |
|
dc.description.abstract |
N-Tosylhydrazones were successfully coupled in the presence of CuI (10 mol%) with various heterocyclic amines to develop a convenient and high yielding protocol for the preparation of N-benzylaminoheterocycles under microwave irradiation. This ligand-free new methodology uses readily available starting materials and a cheaper copper catalyst. A wide range of O, N and S containing heteroarylamines and o-phenylenediamine were explored to prepare N-benzylaminoheterocycles and 1,2-disubstituted benzimidazoles. The protocol was equally effective with N-tosylhydrazones derived from aldehydes and ketones, especially ferrocene aldehyde to prepare an array of N-benzylaminoheterocycles in good to excellent yields. Finally, the identified reaction conditions were utilized to prepare drug-like molecules namely pyrido[1,2-a]benzimidazole and N-substituted-2-amino-thiazole derivative as antitubercular agents. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.subject |
Chemistry |
en_US |
dc.subject |
Synthesis |
en_US |
dc.subject |
N-Benzylaminoheterocycles |
en_US |
dc.subject |
N-Tosylhydrazones |
en_US |
dc.title |
Cu–Catalyzed Expeditious Synthesis of N-Benzylaminoheter-ocycles Using N-Tosylhydrazones and Aminoheteroarenes |
en_US |
dc.type |
Article |
en_US |