| dc.contributor.author | Kumar, Dalip | |
| dc.date.accessioned | 2021-10-27T04:20:26Z | |
| dc.date.available | 2021-10-27T04:20:26Z | |
| dc.date.issued | 2013-06 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960894X13004666?via%3Dihub | |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3042 | |
| dc.description.abstract | A novel cationic porphyrin–quinoxaline conjugate 8 was prepared in good yield by the coupling of activated quinoxaline carboxylic acid 5 with an appropriate aminoporphyrin. The UV–vis spectra of conjugate 8 with the addition of ctDNA shows substantial hypochromicity (39%) and a red shift (12 nm) in the Soret band indicating intercalation and self stacking along the surface. The binding constant of conjugate 8 with ctDNA was determined to be 1.26 × 106 M−1. The porphyrin–quinoxaline conjugate 8 displayed enhanced photocytotoxicity (IC50 = 0.06 μM) when compared to TMPyP against A549 cancer cells. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsiever | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | Porphyrin conjugate | en_US |
| dc.subject | Quinoxaline | en_US |
| dc.subject | Photocytotoxicity | en_US |
| dc.title | Cationic porphyrin–quinoxaline conjugate as a photochemically triggered novel cytotoxic agent | en_US |
| dc.type | Article | en_US |
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