dc.contributor.author |
Kumar, Dalip |
|
dc.date.accessioned |
2021-10-27T04:20:38Z |
|
dc.date.available |
2021-10-27T04:20:38Z |
|
dc.date.issued |
2012-09 |
|
dc.identifier.uri |
https://experts.umn.edu/en/publications/a-series-of-2-arylamino-5-indolyl-134-thiadiazoles-as-potent-cyto |
|
dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3047 |
|
dc.description.abstract |
A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles 6a-v were prepared and studied for their anticancer activity against selected human cancer cell lines. The reaction of indolylhydrazides 3a-h with a variety of aryl isothiocyanates 4 afforded the key intermediate thiosemicarbazides 5a-v, which upon treatment with acetyl chloride produced the 2-arylamino-5-(indolyl)-1,3,4- thiadiazoles 6a-v in good yields. Most of the synthesized compounds showed selective cytotoxicity towards human breast cancer cell line (MDA-MB-231). Of the synthesized 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles, compound 6f is the most potent towards tested cancer cell lines (IC50 = 0.15-1.18 μM). |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
EJMC |
en_US |
dc.subject |
Chemistry |
en_US |
dc.subject |
Potent cytotoxic |
en_US |
dc.subject |
1,3,4-Thiadiazoles |
en_US |
dc.subject |
2-Arylamino-1,3,4-thiadiazoles |
en_US |
dc.subject |
Cytotoxic agents |
en_US |
dc.subject |
Indolyl heterocycles |
en_US |
dc.title |
A series of 2-arylamino-5-(indolyl)-1,3,4-thiadiazoles as potent cytotoxic agents |
en_US |
dc.type |
Article |
en_US |