dc.contributor.author | Kumar, Dalip | |
dc.date.accessioned | 2021-10-27T04:20:48Z | |
dc.date.available | 2021-10-27T04:20:48Z | |
dc.date.issued | 2012-01 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960894X11015721?via%3Dihub | |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3050 | |
dc.description.abstract | A series of bis(indolyl) hydrazide–hydrazones 5a–n were synthesized and evaluated for their cytotoxicity against selected human cancer cell lines. The reaction of indole-3-carboxaldehyde 2 with indole-3-carbohydrazide 4 in presence of catalytic amount of acetic acid afforded 5a–n in good yields. Among the synthesized bis(indolyl)hydrazide–hydrazones, the compound 5b with N-(p-chlorobenzyl) and bromo substituents was found to be the most potent against multiple cancer cell lines (IC50 = 1.0 μM, MDA-MB-231). The compound 5k exhibited selective cytotoxicity against breast cancer cell line MCF7 (IC50 = 3.1 μM). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsiever | en_US |
dc.subject | Chemistry | en_US |
dc.subject | Bisindoles | en_US |
dc.subject | Hydrazide–hydrazone | en_US |
dc.subject | Anticancer agents | en_US |
dc.subject | Bis(indole) alkaloids | en_US |
dc.title | Novel bis(indolyl)hydrazide–hydrazones as potent cytotoxic agents | en_US |
dc.type | Article | en_US |
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