dc.contributor.author | Kumar, Dalip | |
dc.date.accessioned | 2021-10-27T04:20:57Z | |
dc.date.available | 2021-10-27T04:20:57Z | |
dc.date.issued | 2011-04 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960894X11002678?via%3Dihub | |
dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3053 | |
dc.description.abstract | A series of 2-arylamino-5-aryl-1,3,4-thiadiazoles 1a–j were synthesized and screened for their anticancer activity against various human cancer cell lines. The novel one-pot synthesis of 1,3,4-thiadiazoles was achieved by refluxing aryl aldehydes, hydrazine hydrate, and aryl isothiocyanates in methanol followed by oxidative cyclization with ferric ammonium sulfate. The compounds 1g–j with trimethoxyphenyl at the C-5 position displayed extremely potent anticancer activity with at least twofold selectivity (IC50: 4.3–9.2 μM). The nature of substituent on the C-2 arylamino ring may be critical in opting for the selectivity towards a particular cancer cell. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsiever | en_US |
dc.subject | Chemistry | en_US |
dc.subject | 1,3,4-Thidiazoles | en_US |
dc.subject | Anticancer agents | en_US |
dc.subject | One-pot synthesis | en_US |
dc.subject | Cancer cell lines | en_US |
dc.subject | Oxidative cyclization | en_US |
dc.title | One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles | en_US |
dc.type | Article | en_US |
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