| dc.contributor.author | Kumar, Dalip | |
| dc.date.accessioned | 2021-10-27T04:21:32Z | |
| dc.date.available | 2021-10-27T04:21:32Z | |
| dc.date.issued | 2009-08-01 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0960894X09004594?via%3Dihub | |
| dc.identifier.uri | http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3064 | |
| dc.description.abstract | A facile, convenient and high yielding synthesis of a series of novel 5-(3′-indolyl)-2-(substituted)-1,3,4-oxadiazoles from readily available starting materials has been described. The key step of this protocol is oxidative cyclization of N-acylhydrazones 1 using [bis(trifluoroacetoxy)iodo]benzene under solvent-free condition. The 5-(3′-indolyl)-2-(substituted)-1,3,4-oxadiazoles were screened for their in vitro anticancer activity against various human cancer cell lines. Compounds 3c, 3d and 3j exhibited potent cytotoxicity (IC50 ∼1 μM) and selectivity against human cancer cell lines. | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsiever | en_US |
| dc.subject | Chemistry | en_US |
| dc.subject | 1,3,4-Oxadiazole | en_US |
| dc.subject | Solvent-free | en_US |
| dc.subject | Hypervalent iodine | en_US |
| dc.subject | Anticancer agent | en_US |
| dc.subject | Selective cytotoxicity | en_US |
| dc.title | An efficient synthesis and biological study of novel indolyl-1,3,4-oxadiazoles as potent anticancer agents | en_US |
| dc.type | Article | en_US |
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