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Conformation and ortho steric effects in a series of 2-(pyrazol-1-yl)quinolines

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dc.contributor.author Kumar, Dalip
dc.date.accessioned 2021-10-27T04:24:18Z
dc.date.available 2021-10-27T04:24:18Z
dc.date.issued 1996-04
dc.identifier.uri https://onlinelibrary.wiley.com/doi/10.1002/jhet.5570330219
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3109
dc.description.abstract Nine 2-(pyrazol-1-yl)-4-methylquinolines bearing substituents on the pyrazole 3- or 5-positions (H, Me, Et, i-Pr, t-Bu) were regioselectively synthesized either using the direct condensation of 2-chloro-4-methylquinoline and sodium salt of 3(5)-substituted pyrazoles or by treatment of 2-hydrazino-4-methylquinoline with an appropriate β-ketoaldehyde. The 1H and 13C chemical shifts were discussed taking into account the preferred conformation about the C-2-N-1′ bond as calculated by the AM1 Hamiltonian. It appears that 5-ethyl and 5-isopropyl substituted derivatives present short C-H-N-1 interactions. Ortho steric effects appear to be responsible for these conformations. en_US
dc.language.iso en en_US
dc.publisher Wiley en_US
dc.subject Chemistry en_US
dc.subject 2-(pyrazol-1-yl)quinolines en_US
dc.title Conformation and ortho steric effects in a series of 2-(pyrazol-1-yl)quinolines en_US
dc.type Article en_US


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