dc.contributor.author |
Kumar, Dalip |
|
dc.date.accessioned |
2021-10-27T04:24:18Z |
|
dc.date.available |
2021-10-27T04:24:18Z |
|
dc.date.issued |
1996-04 |
|
dc.identifier.uri |
https://onlinelibrary.wiley.com/doi/10.1002/jhet.5570330219 |
|
dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3109 |
|
dc.description.abstract |
Nine 2-(pyrazol-1-yl)-4-methylquinolines bearing substituents on the pyrazole 3- or 5-positions (H, Me, Et, i-Pr, t-Bu) were regioselectively synthesized either using the direct condensation of 2-chloro-4-methylquinoline and sodium salt of 3(5)-substituted pyrazoles or by treatment of 2-hydrazino-4-methylquinoline with an appropriate β-ketoaldehyde. The 1H and 13C chemical shifts were discussed taking into account the preferred conformation about the C-2-N-1′ bond as calculated by the AM1 Hamiltonian. It appears that 5-ethyl and 5-isopropyl substituted derivatives present short C-H-N-1 interactions. Ortho steric effects appear to be responsible for these conformations. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Wiley |
en_US |
dc.subject |
Chemistry |
en_US |
dc.subject |
2-(pyrazol-1-yl)quinolines |
en_US |
dc.title |
Conformation and ortho steric effects in a series of 2-(pyrazol-1-yl)quinolines |
en_US |
dc.type |
Article |
en_US |