| dc.contributor.author |
Kumar, Indresh |
|
| dc.date.accessioned |
2021-10-27T04:27:24Z |
|
| dc.date.available |
2021-10-27T04:27:24Z |
|
| dc.date.issued |
2018-06 |
|
| dc.identifier.uri |
https://pubs.acs.org/doi/10.1021/acs.joc.8b01232 |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3163 |
|
| dc.description.abstract |
An efficient protocol for the catalytic asymmetric synthesis of new dibenzo[b,f][1,4]-oxazepine-fused 1,2-dihydropyridines (DHPs) has been described under metal-free conditions. This reaction proceeds through proline-catalyzed direct Mannich/cyclization between seven-membered dibenzo[b,f][1,4]-oxazepine-imines and aqueous glutaraldehyde, followed by IBX-mediated site-selective dehydrogenative oxidation in one-pot operation with high yields (up to 92%) and excellent enantioselectivity (up to >99:1 er). |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
ACS |
en_US |
| dc.subject |
Chemistry |
en_US |
| dc.subject |
Catalysts |
en_US |
| dc.subject |
Oxidation |
en_US |
| dc.subject |
Reaction products |
en_US |
| dc.title |
One-Pot Synthesis of Chiral Tetracyclic Dibenzo[ b, f][1,4]oxazepine-Fused 1,2-Dihydropyridines (DHPs) under Metal-Free Conditions |
en_US |
| dc.type |
Article |
en_US |