| dc.contributor.author |
Kumar, Indresh |
|
| dc.date.accessioned |
2021-10-27T04:27:27Z |
|
| dc.date.available |
2021-10-27T04:27:27Z |
|
| dc.date.issued |
2018 |
|
| dc.identifier.uri |
https://pubs.rsc.org/en/content/articlelanding/2018/ra/c8ra01637b |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3164 |
|
| dc.description.abstract |
An efficient sequential multi-component method for the synthesis of N-arylpyrrole-3-carbaldehydes has been developed. This reaction involved a proline-catalyzed direct Mannich reaction-cyclization sequence between succinaldehyde and in situ generated Ar/HetAr/indolyl-imines, followed by IBX-mediated oxidative aromatization in one-pot operation. The practical utility of this procedure is shown at gram-scale and the synthesis of diverse bioactive fused heterocyclic scaffolds such as pyrroloquinoline, pyrrolo-oxadiazole, dihydro pyrroloquinoline, and pyrrolo-phenanthridine. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
RSC |
en_US |
| dc.subject |
Chemistry |
en_US |
| dc.subject |
Multicomponent reaction |
en_US |
| dc.subject |
Heterocycles |
en_US |
| dc.subject |
Pyrrole-3-carbaldehydes |
en_US |
| dc.title |
One-pot sequential multicomponent reaction between in situ generated aldimines and succinaldehyde: facile synthesis of substituted pyrrole-3-carbaldehydes and applications towards medicinally important fused heterocycles |
en_US |
| dc.type |
Article |
en_US |