| dc.contributor.author |
Kumar, Indresh |
|
| dc.date.accessioned |
2021-10-27T04:27:36Z |
|
| dc.date.available |
2021-10-27T04:27:36Z |
|
| dc.date.issued |
2016 |
|
| dc.identifier.uri |
https://pubs.rsc.org/en/content/articlelanding/2016/ra/c6ra12965j |
|
| dc.identifier.uri |
http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3168 |
|
| dc.description.abstract |
An enantioselective multi-component synthesis of 1,2,5,6-tetrahydropyridines (THPs) has been developed through a one-pot domino-process. This transformation proceeds through proline-catalyzed direct Mannich reaction-cyclization of glutaraldehyde with in situ generated imines, followed by site-selective oxidation–reduction sequence under mild conditions. Chiral 1,2,5,6-THPs are obtained in good to high yields (up to 80%) and with the excellent enantioselectivity (up to 98 : 2 er). The usefulness of this operationally simple method is also shown to synthesize other medicinally important nitrogen-heterocycles. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.publisher |
RSC |
en_US |
| dc.subject |
Chemistry |
en_US |
| dc.subject |
Synthesis |
en_US |
| dc.subject |
N-heterocycles |
en_US |
| dc.title |
Enantioselective synthesis of 1,2,5,6-tetrahydropyridines (THPs) via proline-catalyzed direct Mannich-cyclization/domino oxidation–reduction sequence: application for medicinally important N-heterocycles |
en_US |
| dc.type |
Article |
en_US |