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An organocatalytic direct Mannich–cyclization cascade as [3+2] annulation: asymmetric synthesis of 2,3-substituted pyrrolidines

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dc.contributor.author Kumar, Indresh
dc.date.accessioned 2021-10-27T04:28:07Z
dc.date.available 2021-10-27T04:28:07Z
dc.date.issued 2012
dc.identifier.uri https://pubs.rsc.org/en/content/articlelanding/2012/cc/c2cc33103a
dc.identifier.uri http://dspace.bits-pilani.ac.in:8080/xmlui/handle/123456789/3178
dc.description.abstract A new method for asymmetric synthesis of 2,3-substituted pyrrolidines from N-PMP aldimines and succinaldehyde via formal [3+2] cycloaddition is reported. This reaction involves proline catalyzed direct Mannich reaction and acid catalyzed reductive cyclization with high yields (up to 78%) and excellent enantioselectivities (up to >99%). en_US
dc.language.iso en en_US
dc.publisher RSC en_US
dc.subject Chemistry en_US
dc.subject Organocatalytic en_US
dc.subject Mannich–cyclization en_US
dc.subject Pyrrolidines en_US
dc.title An organocatalytic direct Mannich–cyclization cascade as [3+2] annulation: asymmetric synthesis of 2,3-substituted pyrrolidines en_US
dc.type Article en_US


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