Abstract:
The Label-Assisted Laser Desorption/Ionization (LA-LDI) technique has recently been applied to the detection of small molecules through a Time of Flight (TOF) mass spectrometric measurement. By excluding the external matrix, the mass spectrum becomes a lot cleaner being free of matrix-related peaks and noise. In this paper, we report a Label-Assisted Laser Desorption/Ionization Mass Spectrometry (LA-LDI-MS) based method for detection of various cis-1,2-diols, including the ones ubiquitous in biological samples.